Mitophagy in ischemic heart disease: molecular mechanisms and clinical management
Abstract The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published revie...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-12-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-07303-3 |
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| _version_ | 1841559104574717952 |
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| author | Shujuan Xu Zihan Wang Fan Guo Yehao Zhang Han Peng Huiyu Zhang Zixin Liu Ce Cao Gaojie Xin Yuan Yuan Chen Jianhua Fu |
| author_facet | Shujuan Xu Zihan Wang Fan Guo Yehao Zhang Han Peng Huiyu Zhang Zixin Liu Ce Cao Gaojie Xin Yuan Yuan Chen Jianhua Fu |
| author_sort | Shujuan Xu |
| collection | DOAJ |
| description | Abstract The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published reviews have not explored in detail the unique function of mitophagy in ischemic heart disease, therefore, the aim of this paper is to summarize how mitophagy regulates the progression of ischemic heart disease. We conclude that mitophagy affects ischemic heart disease by promoting cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, the development of inflammation, and cardiomyocyte death, and that the specific mechanisms of mitophagy are worthy of further investigation. |
| format | Article |
| id | doaj-art-e6f1bc6ce4c74c929293a2671d36841a |
| institution | Kabale University |
| issn | 2041-4889 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-e6f1bc6ce4c74c929293a2671d36841a2025-01-05T12:48:08ZengNature Publishing GroupCell Death and Disease2041-48892024-12-01151211310.1038/s41419-024-07303-3Mitophagy in ischemic heart disease: molecular mechanisms and clinical managementShujuan Xu0Zihan Wang1Fan Guo2Yehao Zhang3Han Peng4Huiyu Zhang5Zixin Liu6Ce Cao7Gaojie Xin8Yuan Yuan Chen9Jianhua Fu10Xiyuan Hospital of China Academy of Chinese Medical SciencesDepartment of Oral Implantology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral DiseasesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesAbstract The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published reviews have not explored in detail the unique function of mitophagy in ischemic heart disease, therefore, the aim of this paper is to summarize how mitophagy regulates the progression of ischemic heart disease. We conclude that mitophagy affects ischemic heart disease by promoting cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, the development of inflammation, and cardiomyocyte death, and that the specific mechanisms of mitophagy are worthy of further investigation.https://doi.org/10.1038/s41419-024-07303-3 |
| spellingShingle | Shujuan Xu Zihan Wang Fan Guo Yehao Zhang Han Peng Huiyu Zhang Zixin Liu Ce Cao Gaojie Xin Yuan Yuan Chen Jianhua Fu Mitophagy in ischemic heart disease: molecular mechanisms and clinical management Cell Death and Disease |
| title | Mitophagy in ischemic heart disease: molecular mechanisms and clinical management |
| title_full | Mitophagy in ischemic heart disease: molecular mechanisms and clinical management |
| title_fullStr | Mitophagy in ischemic heart disease: molecular mechanisms and clinical management |
| title_full_unstemmed | Mitophagy in ischemic heart disease: molecular mechanisms and clinical management |
| title_short | Mitophagy in ischemic heart disease: molecular mechanisms and clinical management |
| title_sort | mitophagy in ischemic heart disease molecular mechanisms and clinical management |
| url | https://doi.org/10.1038/s41419-024-07303-3 |
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