Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid
To examine inflammatory tissue, an initial and common symptom of various types of pathogenesis, we designed inflammation-targeted T 1 contrast agents prepared by bioconjugation of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with anti-intercellular adhesion molecule 1 (ICAM-1) antibody. T...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2007-03-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2007.00005 |
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| author | Kyu-Sil Choi Sun-Hee Kim Quan-Yu Cai Soo-Yeon Kim Hyang-Ok Kim Hye-Jin Lee Eun-A Kim Seong-Eon Yoon Ki-Jung Yun Kwon-Ha Yoon |
| author_facet | Kyu-Sil Choi Sun-Hee Kim Quan-Yu Cai Soo-Yeon Kim Hyang-Ok Kim Hye-Jin Lee Eun-A Kim Seong-Eon Yoon Ki-Jung Yun Kwon-Ha Yoon |
| author_sort | Kyu-Sil Choi |
| collection | DOAJ |
| description | To examine inflammatory tissue, an initial and common symptom of various types of pathogenesis, we designed inflammation-targeted T 1 contrast agents prepared by bioconjugation of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with anti-intercellular adhesion molecule 1 (ICAM-1) antibody. The anti-ICAM-1 antibody was coupled with DTPA and was then conjugated with Gd. The specific binding of the Gd-DTPA-anti-ICAM-1 antibody complex to the ICAM-1-expressing cells was examined in the cultured endothelial cells where ICAM-1 expression was stimulated. Inflammation-specific T 1 imaging was then assessed using a mouse abscess model with the 1.5-Tesla module. The Gd-DTPA-anti-ICAM-1 antibody displayed increased r1, which was two times higher than that of Gd-DTPA and showed predominant binding to cultured endothelial cells, which expressed a high level of ICAM-1. Moreover, the inflammation-specific T 1 enhancement was imaged with the Gd-DTPA-anti-ICAM-1 antibody in the mouse acute inflammation model. The Gd-DTPA-anti-ICAM-1 antibody showed significantly increased vascular circulation time, which thereby offered a greater chance for its binding to the target cells. The Gd-DTPA-anti-ICAM-1 antibody displays a potential targeted T 1 contrast agent specific to the inflammatory tissue that expresses ICAM-1. |
| format | Article |
| id | doaj-art-e6d65f4387924c949d624f501624cff3 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2007-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-e6d65f4387924c949d624f501624cff32025-01-02T21:31:15ZengSAGE PublishingMolecular Imaging1536-01212007-03-01610.2310/7290.2007.0000510.2310_7290.2007.00005Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic AcidKyu-Sil ChoiSun-Hee KimQuan-Yu CaiSoo-Yeon KimHyang-Ok KimHye-Jin LeeEun-A KimSeong-Eon YoonKi-Jung YunKwon-Ha YoonTo examine inflammatory tissue, an initial and common symptom of various types of pathogenesis, we designed inflammation-targeted T 1 contrast agents prepared by bioconjugation of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with anti-intercellular adhesion molecule 1 (ICAM-1) antibody. The anti-ICAM-1 antibody was coupled with DTPA and was then conjugated with Gd. The specific binding of the Gd-DTPA-anti-ICAM-1 antibody complex to the ICAM-1-expressing cells was examined in the cultured endothelial cells where ICAM-1 expression was stimulated. Inflammation-specific T 1 imaging was then assessed using a mouse abscess model with the 1.5-Tesla module. The Gd-DTPA-anti-ICAM-1 antibody displayed increased r1, which was two times higher than that of Gd-DTPA and showed predominant binding to cultured endothelial cells, which expressed a high level of ICAM-1. Moreover, the inflammation-specific T 1 enhancement was imaged with the Gd-DTPA-anti-ICAM-1 antibody in the mouse acute inflammation model. The Gd-DTPA-anti-ICAM-1 antibody showed significantly increased vascular circulation time, which thereby offered a greater chance for its binding to the target cells. The Gd-DTPA-anti-ICAM-1 antibody displays a potential targeted T 1 contrast agent specific to the inflammatory tissue that expresses ICAM-1.https://doi.org/10.2310/7290.2007.00005 |
| spellingShingle | Kyu-Sil Choi Sun-Hee Kim Quan-Yu Cai Soo-Yeon Kim Hyang-Ok Kim Hye-Jin Lee Eun-A Kim Seong-Eon Yoon Ki-Jung Yun Kwon-Ha Yoon Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid Molecular Imaging |
| title | Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid |
| title_full | Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid |
| title_fullStr | Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid |
| title_full_unstemmed | Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid |
| title_short | Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid |
| title_sort | inflammation specific t imaging using anti intercellular adhesion molecule 1 antibody conjugated gadolinium diethylenetriaminepentaacetic acid |
| url | https://doi.org/10.2310/7290.2007.00005 |
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