Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly
Objective: Chromosome abnormalities play an important role in male infertility. The rate of chromosome disorders in infertile men is higher as 5.8% when compared to the normal population (0.5%). Methods: This study aimed to determine the frequency of cytogenetic abnormalities in infertile men with...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-01-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/frequency-of-chromosome-disorders-in-patients-with-sperm-number-anomaly/doi/gmj.2024.4170 |
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| author | Mehmet Niyaz Egzon Abdullahı Zerrin Yılmaz Çelik |
| author_facet | Mehmet Niyaz Egzon Abdullahı Zerrin Yılmaz Çelik |
| author_sort | Mehmet Niyaz |
| collection | DOAJ |
| description | Objective: Chromosome abnormalities play an important role in male infertility. The rate of chromosome disorders in infertile men is higher as 5.8% when compared to the normal population (0.5%).
Methods: This study aimed to determine the frequency of cytogenetic abnormalities in infertile men with abnormal sperm counts and to show that rare chromosomal rearrangements can be detected by karyotyping.
Results: In our clinical practice, we detected nearly all chromosome numerical and structural anomalies involved in infertility. It includes inversions, translocations, deletions, insertions, complex rearrangements, isochromosomes, Klinefelter syndrome, mosaicism, and 47, XYY.
Conclusion: Our results emphasize the importance of conventional cytogenetic analysis for infertile males. The detection of rare or known chromosome abnormalities will prevent unnecessary investigations and enable us the application of precision in medicine. |
| format | Article |
| id | doaj-art-e6bc490301e345728851b1735506416d |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-e6bc490301e345728851b1735506416d2025-01-13T11:43:37ZengGalenos Publishing HouseGazi Medical Journal2147-20922025-01-01361747910.12996/gmj.2024.4170Frequency of Chromosome Disorders In Patients with Sperm Number AnomalyMehmet Niyaz0https://orcid.org/0000-0003-2622-0012Egzon Abdullahı1https://orcid.org/0000-0003-3809-6127Zerrin Yılmaz Çelik2https://orcid.org/0000-0001-9158-220XDepartment of Medical Genetics Başkent University Faculty of Medicine, Ankara, TürkiyeDepartment of Medical Genetics Başkent University Faculty of Medicine, Ankara, TürkiyeDepartment of Medical Genetics Başkent University Faculty of Medicine, Ankara, TürkiyeObjective: Chromosome abnormalities play an important role in male infertility. The rate of chromosome disorders in infertile men is higher as 5.8% when compared to the normal population (0.5%). Methods: This study aimed to determine the frequency of cytogenetic abnormalities in infertile men with abnormal sperm counts and to show that rare chromosomal rearrangements can be detected by karyotyping. Results: In our clinical practice, we detected nearly all chromosome numerical and structural anomalies involved in infertility. It includes inversions, translocations, deletions, insertions, complex rearrangements, isochromosomes, Klinefelter syndrome, mosaicism, and 47, XYY. Conclusion: Our results emphasize the importance of conventional cytogenetic analysis for infertile males. The detection of rare or known chromosome abnormalities will prevent unnecessary investigations and enable us the application of precision in medicine.https://gazimedj.com/articles/frequency-of-chromosome-disorders-in-patients-with-sperm-number-anomaly/doi/gmj.2024.4170abnormal sperm countschromosome abnormalitiesgenetic counselling |
| spellingShingle | Mehmet Niyaz Egzon Abdullahı Zerrin Yılmaz Çelik Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly Gazi Medical Journal abnormal sperm counts chromosome abnormalities genetic counselling |
| title | Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly |
| title_full | Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly |
| title_fullStr | Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly |
| title_full_unstemmed | Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly |
| title_short | Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly |
| title_sort | frequency of chromosome disorders in patients with sperm number anomaly |
| topic | abnormal sperm counts chromosome abnormalities genetic counselling |
| url | https://gazimedj.com/articles/frequency-of-chromosome-disorders-in-patients-with-sperm-number-anomaly/doi/gmj.2024.4170 |
| work_keys_str_mv | AT mehmetniyaz frequencyofchromosomedisordersinpatientswithspermnumberanomaly AT egzonabdullahı frequencyofchromosomedisordersinpatientswithspermnumberanomaly AT zerrinyılmazcelik frequencyofchromosomedisordersinpatientswithspermnumberanomaly |