Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis
Abstract This study investigated the association between NAFLD and liver fibrosis and the ratio of gamma-glutamyl transferase to high-density lipoprotein cholesterol (GGT/HDL-C). In this cross-sectional study, we included 4764 subjects who participated in the National Health and Nutrition Examinatio...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84649-w |
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| author | Yanyan Xuan Fangfang He Qing Liu Dandan Dai Dingting Wu Yanmei Shi Qi Yao |
| author_facet | Yanyan Xuan Fangfang He Qing Liu Dandan Dai Dingting Wu Yanmei Shi Qi Yao |
| author_sort | Yanyan Xuan |
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| description | Abstract This study investigated the association between NAFLD and liver fibrosis and the ratio of gamma-glutamyl transferase to high-density lipoprotein cholesterol (GGT/HDL-C). In this cross-sectional study, we included 4764 subjects who participated in the National Health and Nutrition Examination Survey (NHANES) during 2017–2018. Adjusted multivariate logistic regression analysis was utilized to evaluate the relationships between GGT/HDL-C levels and NAFLD, fatty liver degree, and liver fibrosis. The non-linear link between NAFLD and the GGT/HDL-C ratio was examined using generalized additive models. There was a non-linear association between GGT/HDL-C and the risk of NAFLD, and all regression models demonstrated a strong relationship between GGT/HDL-C levels and the risk of liver fibrosis, the degree of hepatic steatosis, and the prevalence of NAFLD. Subgroup analyses revealed a significant correlation between the risk of NAFLD and the GGT/HDL-C ratio among Mexican Americans and young people in the 20–40 age range. The receiver operating characteristic (ROC) study showed that GGT/HDL-C was a more accurate predictor of NAFLD than GGT or HDL-C alone. In the U.S. population, an increased risk of NAFLD, the severity of hepatic steatosis, and the risk of liver fibrosis are independently correlated with an elevated GGT/HDL-C ratio. |
| format | Article |
| id | doaj-art-e6b5dc5924ab4b3a866c8f33bbab30cc |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-e6b5dc5924ab4b3a866c8f33bbab30cc2025-01-05T12:15:06ZengNature PortfolioScientific Reports2045-23222025-01-0115111710.1038/s41598-024-84649-wElevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosisYanyan Xuan0Fangfang He1Qing Liu2Dandan Dai3Dingting Wu4Yanmei Shi5Qi Yao6Department of Hospital Infection, The First Affiliated Hospital of Ningbo UniversityDepartment of Hospital Infection, The First Affiliated Hospital of Ningbo UniversityDepartment of Hepatology, The First Affiliated Hospital of Ningbo UniversityDepartment of Pharmacy, The First Affiliated Hospital of Ningbo UniversityDepartment of Clinical Nutrition, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Hepatology, The First Affiliated Hospital of Ningbo UniversityDepartment of Geriatrics Medicine, The First Affiliated Hospital of Ningbo UniversityAbstract This study investigated the association between NAFLD and liver fibrosis and the ratio of gamma-glutamyl transferase to high-density lipoprotein cholesterol (GGT/HDL-C). In this cross-sectional study, we included 4764 subjects who participated in the National Health and Nutrition Examination Survey (NHANES) during 2017–2018. Adjusted multivariate logistic regression analysis was utilized to evaluate the relationships between GGT/HDL-C levels and NAFLD, fatty liver degree, and liver fibrosis. The non-linear link between NAFLD and the GGT/HDL-C ratio was examined using generalized additive models. There was a non-linear association between GGT/HDL-C and the risk of NAFLD, and all regression models demonstrated a strong relationship between GGT/HDL-C levels and the risk of liver fibrosis, the degree of hepatic steatosis, and the prevalence of NAFLD. Subgroup analyses revealed a significant correlation between the risk of NAFLD and the GGT/HDL-C ratio among Mexican Americans and young people in the 20–40 age range. The receiver operating characteristic (ROC) study showed that GGT/HDL-C was a more accurate predictor of NAFLD than GGT or HDL-C alone. In the U.S. population, an increased risk of NAFLD, the severity of hepatic steatosis, and the risk of liver fibrosis are independently correlated with an elevated GGT/HDL-C ratio.https://doi.org/10.1038/s41598-024-84649-wNAFLDHigh-density lipoprotein cholesterolGamma-glutamyl transferaseSteatosisFibrosis |
| spellingShingle | Yanyan Xuan Fangfang He Qing Liu Dandan Dai Dingting Wu Yanmei Shi Qi Yao Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis Scientific Reports NAFLD High-density lipoprotein cholesterol Gamma-glutamyl transferase Steatosis Fibrosis |
| title | Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis |
| title_full | Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis |
| title_fullStr | Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis |
| title_full_unstemmed | Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis |
| title_short | Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis |
| title_sort | elevated ggt to hdl ratio as a marker for the risk of nafld and liver fibrosis |
| topic | NAFLD High-density lipoprotein cholesterol Gamma-glutamyl transferase Steatosis Fibrosis |
| url | https://doi.org/10.1038/s41598-024-84649-w |
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