Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration
The dehydrated human amnion–chorion membranes (dHACMs) derived from the human placenta have emerged as a promising biomaterial for dental pulp regeneration owing to their unique biological and structural properties. The purpose of this review is to explore the potentials of dHACMs in dental pulp tis...
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MDPI AG
2024-12-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/9/12/771 |
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| author | Sahng G. Kim |
| author_facet | Sahng G. Kim |
| author_sort | Sahng G. Kim |
| collection | DOAJ |
| description | The dehydrated human amnion–chorion membranes (dHACMs) derived from the human placenta have emerged as a promising biomaterial for dental pulp regeneration owing to their unique biological and structural properties. The purpose of this review is to explore the potentials of dHACMs in dental pulp tissue engineering, focusing on their ability to promote cellular proliferation, differentiation, angiogenesis, and neurogenesis. dHACMs are rich in extracellular matrix proteins and growth factors such as TGF-β1, FGF2, and VEGF. They also exhibit significant anti-inflammatory and antimicrobial properties, creating an optimal environment for dental pulp regeneration. The applications of dHACMs in regenerative endodontic procedures are discussed, highlighting their ability to support the formation of dentin and well-vascularized pulp-like tissue. This review demonstrates that dHACMs hold significant potential for enhancing the success of pulp regeneration and offer a biologically based approach to preserve tooth vitality and improve tooth survival. Future research is expected to focus on conducting long-term clinical studies to establish their efficacy and safety. |
| format | Article |
| id | doaj-art-e68d48203df8461f955ff1f808d3cda3 |
| institution | Kabale University |
| issn | 2313-7673 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj-art-e68d48203df8461f955ff1f808d3cda32024-12-27T14:13:31ZengMDPI AGBiomimetics2313-76732024-12-0191277110.3390/biomimetics9120771Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue RegenerationSahng G. Kim0Division of Endodontics, Columbia University College of Dental Medicine, New York, NY 10032, USAThe dehydrated human amnion–chorion membranes (dHACMs) derived from the human placenta have emerged as a promising biomaterial for dental pulp regeneration owing to their unique biological and structural properties. The purpose of this review is to explore the potentials of dHACMs in dental pulp tissue engineering, focusing on their ability to promote cellular proliferation, differentiation, angiogenesis, and neurogenesis. dHACMs are rich in extracellular matrix proteins and growth factors such as TGF-β1, FGF2, and VEGF. They also exhibit significant anti-inflammatory and antimicrobial properties, creating an optimal environment for dental pulp regeneration. The applications of dHACMs in regenerative endodontic procedures are discussed, highlighting their ability to support the formation of dentin and well-vascularized pulp-like tissue. This review demonstrates that dHACMs hold significant potential for enhancing the success of pulp regeneration and offer a biologically based approach to preserve tooth vitality and improve tooth survival. Future research is expected to focus on conducting long-term clinical studies to establish their efficacy and safety.https://www.mdpi.com/2313-7673/9/12/771amnion–chorion membranesdental pulp regenerationregenerative endodonticsbioactive scaffoldsbiomaterials |
| spellingShingle | Sahng G. Kim Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration Biomimetics amnion–chorion membranes dental pulp regeneration regenerative endodontics bioactive scaffolds biomaterials |
| title | Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration |
| title_full | Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration |
| title_fullStr | Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration |
| title_full_unstemmed | Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration |
| title_short | Dehydrated Human Amnion–Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration |
| title_sort | dehydrated human amnion chorion membrane as a bioactive scaffold for dental pulp tissue regeneration |
| topic | amnion–chorion membranes dental pulp regeneration regenerative endodontics bioactive scaffolds biomaterials |
| url | https://www.mdpi.com/2313-7673/9/12/771 |
| work_keys_str_mv | AT sahnggkim dehydratedhumanamnionchorionmembraneasabioactivescaffoldfordentalpulptissueregeneration |