Grapefruit-Derived Vesicles Loaded with Recombinant HSP70 Activate Antitumor Immunity in Colon Cancer In Vitro and In Vivo

Grapefruit-Derived Vesicles Loaded with Recombinant HSP70 Activate Antitumor Immunity in Colon Cancer In Vitro and In Vivo

<b>Background/Objectives:</b> Stress protein HSP70 administered exogenously has demonstrated high potential as an efficient adjuvant in antitumor immune response. To enhance the antigen-presenting activity, bioavailability, and stability of exogenous recombinant human HSP70, we propose i...

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Bibliographic Details
Main Authors: Luiza Garaeva, Elena Komarova, Svetlana Emelianova, Elena Putevich, Andrey L. Konevega, Boris Margulis, Irina Guzhova, Tatiana Shtam
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
HSP70
extracellular vesicles
plant-derived extracellular vesicles
drug delivery systems
antitumor immunity
colon cancer
Online Access:https://www.mdpi.com/2227-9059/12/12/2759
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