Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats
Unmanaged Type 2 Diabetes (DM2) is a known risk factor for cognitive decline, dementia, and Alzheimer's disease (DM3). This study explores the combined effects of high-intensity interval training (HIIT) and thyme honey on the expression of genes involved in memory-related signaling pathways (BD...
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2024-06-01
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| Series: | Journal of Exercise & Organ Cross Talk |
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| author | Shadi Jalalian Hossein Abednatanzi Mandana Gholami Farshad Ghazalian |
| author_facet | Shadi Jalalian Hossein Abednatanzi Mandana Gholami Farshad Ghazalian |
| author_sort | Shadi Jalalian |
| collection | DOAJ |
| description | Unmanaged Type 2 Diabetes (DM2) is a known risk factor for cognitive decline, dementia, and Alzheimer's disease (DM3). This study explores the combined effects of high-intensity interval training (HIIT) and thyme honey on the expression of genes involved in memory-related signaling pathways (BDNF-TrkB-CREB), which are compromised in both DM2 and DM3. This experimental study involved 36 young male Wistar rats, divided into four groups: control (C), HIIT (T), thyme honey (H), and HIIT-thyme honey (TH). The T and TH groups underwent 40 training sessions over two months, with progressively increasing intervals (from 2 to 8) and intensity (from 80% to 95% of maximum running speed). Concurrently, the H and TH groups were administered 3 g/kg of thyme honey 5 days a week. Changes in BDNF, TrkB, and CREB gene expression were assessed using RT-PCR. The data were analyzed through one-way ANOVA, Bonferroni post hoc test, and Univariate analysis using SPSS-22 software. A significant increase in BDNF and CREB expression in the interactive intervention group and the expression of the TrkB gene in honey intervention groups were observed compared to diabetic control (P≥0.001). The interactive intervention with HIIT exercises and thyme honey has a synergistic effect on increasing gene expression in memory-related pathways. The highest effect size was observed for HIIT training on BDNF (EF=0.667) and CREB (EF=0.540), while the honey intervention showed a significant effect size on TrkB (EF=0.666). |
| format | Article |
| id | doaj-art-e671c4f1fcb94cfdafee3fd801e7c218 |
| institution | Kabale University |
| issn | 2783-2074 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | JEOCT publisher |
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| series | Journal of Exercise & Organ Cross Talk |
| spelling | doaj-art-e671c4f1fcb94cfdafee3fd801e7c2182024-12-17T19:30:34ZengJEOCT publisherJournal of Exercise & Organ Cross Talk2783-20742024-06-01429910610.22122/jeoct.2024.482657.1126208794Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic ratsShadi Jalalian0Hossein Abednatanzi1Mandana Gholami2Farshad Ghazalian3Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.Unmanaged Type 2 Diabetes (DM2) is a known risk factor for cognitive decline, dementia, and Alzheimer's disease (DM3). This study explores the combined effects of high-intensity interval training (HIIT) and thyme honey on the expression of genes involved in memory-related signaling pathways (BDNF-TrkB-CREB), which are compromised in both DM2 and DM3. This experimental study involved 36 young male Wistar rats, divided into four groups: control (C), HIIT (T), thyme honey (H), and HIIT-thyme honey (TH). The T and TH groups underwent 40 training sessions over two months, with progressively increasing intervals (from 2 to 8) and intensity (from 80% to 95% of maximum running speed). Concurrently, the H and TH groups were administered 3 g/kg of thyme honey 5 days a week. Changes in BDNF, TrkB, and CREB gene expression were assessed using RT-PCR. The data were analyzed through one-way ANOVA, Bonferroni post hoc test, and Univariate analysis using SPSS-22 software. A significant increase in BDNF and CREB expression in the interactive intervention group and the expression of the TrkB gene in honey intervention groups were observed compared to diabetic control (P≥0.001). The interactive intervention with HIIT exercises and thyme honey has a synergistic effect on increasing gene expression in memory-related pathways. The highest effect size was observed for HIIT training on BDNF (EF=0.667) and CREB (EF=0.540), while the honey intervention showed a significant effect size on TrkB (EF=0.666).https://www.jeoct.com/article_208794_7122bb823afa7302224e5777d6381a10.pdfhiithoneyantioxidantdiabetesbdnfmemoryhippocampus |
| spellingShingle | Shadi Jalalian Hossein Abednatanzi Mandana Gholami Farshad Ghazalian Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats Journal of Exercise & Organ Cross Talk hiit honey antioxidant diabetes bdnf memory hippocampus |
| title | Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats |
| title_full | Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats |
| title_fullStr | Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats |
| title_full_unstemmed | Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats |
| title_short | Neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats |
| title_sort | neuroprotective effects of intense training and thyme honey on hippocampal cognitive pathways in diabetic rats |
| topic | hiit honey antioxidant diabetes bdnf memory hippocampus |
| url | https://www.jeoct.com/article_208794_7122bb823afa7302224e5777d6381a10.pdf |
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