AURKA promotes angiogenesis in uveal melanoma via activation of the JAK2/STAT3/VEGFA signaling pathway

AURKA promotes angiogenesis in uveal melanoma via activation of the JAK2/STAT3/VEGFA signaling pathway

Abstract Purpose Uveal melanoma (UM) is a highly aggressive malignancy with a poor prognosis, where angiogenesis plays a pivotal role in tumor metastasis. Aurora kinase A (AURKA) is widely recognized for its role in regulating cell cycle progression and promoting tumorigenesis; however, its involvem...

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Bibliographic Details
Main Authors: Qingyue Ma, Haowen Wang, Xintong Zhao, Xiaodi Gao, Qian Zhang, Yichong Liu, Yiqing Ji, Ying Sun, Ke Lei, Wenjuan Luo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Cell International
Subjects:
Uveal melanoma
Aurora kinase A
Artesunate
Angiogenesis
JAK2/STAT3 signaling pathway
Online Access:https://doi.org/10.1186/s12935-025-03836-5
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