Primary Large-Cell Neuroendocrine Carcinoma of the Breast
Breast neuroendocrine carcinoma (NECB) is a rare type of breast tumor. Large-cell neuroendocrine carcinomas of the breast (LCNECB) are a special and rare histological subtype of NECB. Here, we present a case of a 59-year-old woman who was diagnosed with an LCNECB. A mass in the upper outer quadrant...
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MDPI AG
2024-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/21/2347 |
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| author | Bicheng Zhang Fengbo Huang Siyu Guo Dang Wu Xiaofang Xiao Ting Zhang |
| author_facet | Bicheng Zhang Fengbo Huang Siyu Guo Dang Wu Xiaofang Xiao Ting Zhang |
| author_sort | Bicheng Zhang |
| collection | DOAJ |
| description | Breast neuroendocrine carcinoma (NECB) is a rare type of breast tumor. Large-cell neuroendocrine carcinomas of the breast (LCNECB) are a special and rare histological subtype of NECB. Here, we present a case of a 59-year-old woman who was diagnosed with an LCNECB. A mass in the upper outer quadrant of the right breast was revealed via imaging. A histological examination showed the tumor cells were composed of clusters of large cells with obvious atypia that were polygonal or irregularly shaped. The patient underwent a right-breast-conserving radical surgery and sentinel lymph node biopsy (SLB). A histopathological examination revealed that the tumor of the right breast was 2.5 × 2 cm in size with vascular invasion, and the sentinel lymph node was negative. The immunohistochemical results showed that the tumor cells were diffuse and positive for chromogranin A (CgA), synaptophysin (Syn), and INSM1. The patient successfully completed chemotherapy and radiotherapy and is currently undergoing endocrine therapy. |
| format | Article |
| id | doaj-art-e643cfaa7dd64d0aac4a50264b49fbf6 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-e643cfaa7dd64d0aac4a50264b49fbf62024-11-08T14:34:37ZengMDPI AGDiagnostics2075-44182024-10-011421234710.3390/diagnostics14212347Primary Large-Cell Neuroendocrine Carcinoma of the BreastBicheng Zhang0Fengbo Huang1Siyu Guo2Dang Wu3Xiaofang Xiao4Ting Zhang5Department of Radiation Oncology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Pathology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Radiation Oncology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Radiation Oncology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Medical Oncology, The Fourth Affiliated Hospital of Zhejiang University, School of Medicine, Yiwu 322000, ChinaDepartment of Radiation Oncology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaBreast neuroendocrine carcinoma (NECB) is a rare type of breast tumor. Large-cell neuroendocrine carcinomas of the breast (LCNECB) are a special and rare histological subtype of NECB. Here, we present a case of a 59-year-old woman who was diagnosed with an LCNECB. A mass in the upper outer quadrant of the right breast was revealed via imaging. A histological examination showed the tumor cells were composed of clusters of large cells with obvious atypia that were polygonal or irregularly shaped. The patient underwent a right-breast-conserving radical surgery and sentinel lymph node biopsy (SLB). A histopathological examination revealed that the tumor of the right breast was 2.5 × 2 cm in size with vascular invasion, and the sentinel lymph node was negative. The immunohistochemical results showed that the tumor cells were diffuse and positive for chromogranin A (CgA), synaptophysin (Syn), and INSM1. The patient successfully completed chemotherapy and radiotherapy and is currently undergoing endocrine therapy.https://www.mdpi.com/2075-4418/14/21/2347breast neuroendocrine carcinomalarge-cell neuroendocrine carcinomasCgASynINSM1 |
| spellingShingle | Bicheng Zhang Fengbo Huang Siyu Guo Dang Wu Xiaofang Xiao Ting Zhang Primary Large-Cell Neuroendocrine Carcinoma of the Breast Diagnostics breast neuroendocrine carcinoma large-cell neuroendocrine carcinomas CgA Syn INSM1 |
| title | Primary Large-Cell Neuroendocrine Carcinoma of the Breast |
| title_full | Primary Large-Cell Neuroendocrine Carcinoma of the Breast |
| title_fullStr | Primary Large-Cell Neuroendocrine Carcinoma of the Breast |
| title_full_unstemmed | Primary Large-Cell Neuroendocrine Carcinoma of the Breast |
| title_short | Primary Large-Cell Neuroendocrine Carcinoma of the Breast |
| title_sort | primary large cell neuroendocrine carcinoma of the breast |
| topic | breast neuroendocrine carcinoma large-cell neuroendocrine carcinomas CgA Syn INSM1 |
| url | https://www.mdpi.com/2075-4418/14/21/2347 |
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