Dawn of an era of effective treatments for MAFLD
Abstract Fatty liver disease is a commonly occurring disease resulting in hepatic and extrahepatic complications. To date, there have been few available treatments beyond conventional lifestyle modification. While lifestyle modifications resulting in weight loss >10% have shown to be beneficial f...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Portal Hypertension & Cirrhosis |
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| Online Access: | https://doi.org/10.1002/poh2.96 |
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| author | Cameron Gofton Jacob George |
| author_facet | Cameron Gofton Jacob George |
| author_sort | Cameron Gofton |
| collection | DOAJ |
| description | Abstract Fatty liver disease is a commonly occurring disease resulting in hepatic and extrahepatic complications. To date, there have been few available treatments beyond conventional lifestyle modification. While lifestyle modifications resulting in weight loss >10% have shown to be beneficial for metabolic dysfunction‐associated steatohepatitis (MASH), for the majority of patients, this is difficult to achieve. The recent approval of resmetirom (a thyroid hormone receptor beta agonist) by the Food and Drug Administration following positive results for histological outcomes in a phase 3 trial has opened the door for new treatments for metabolic (dysfunction)‐associated fatty liver disease (MAFLD) and MASH. There are currently a number of phase 3 trials targeting a variety of signaling pathways involved in the pathogenesis of metabolic steatohepatitis that are also promising. This review focuses on the currently available treatments for MAFLD and MASH, ongoing phase 3 clinical trials, and unresolved controversies in clinical trials in this area. |
| format | Article |
| id | doaj-art-e61d5615bb724d7680dd1debe6f7c0e1 |
| institution | Kabale University |
| issn | 2770-5838 2770-5846 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Portal Hypertension & Cirrhosis |
| spelling | doaj-art-e61d5615bb724d7680dd1debe6f7c0e12024-12-19T06:47:26ZengWileyPortal Hypertension & Cirrhosis2770-58382770-58462024-12-013420621610.1002/poh2.96Dawn of an era of effective treatments for MAFLDCameron Gofton0Jacob George1Storr Liver Centre, The Westmead Institute for Medical Research, Westmead Hospital, University of Sydney Westmead New South Wales AustraliaStorr Liver Centre, The Westmead Institute for Medical Research, Westmead Hospital, University of Sydney Westmead New South Wales AustraliaAbstract Fatty liver disease is a commonly occurring disease resulting in hepatic and extrahepatic complications. To date, there have been few available treatments beyond conventional lifestyle modification. While lifestyle modifications resulting in weight loss >10% have shown to be beneficial for metabolic dysfunction‐associated steatohepatitis (MASH), for the majority of patients, this is difficult to achieve. The recent approval of resmetirom (a thyroid hormone receptor beta agonist) by the Food and Drug Administration following positive results for histological outcomes in a phase 3 trial has opened the door for new treatments for metabolic (dysfunction)‐associated fatty liver disease (MAFLD) and MASH. There are currently a number of phase 3 trials targeting a variety of signaling pathways involved in the pathogenesis of metabolic steatohepatitis that are also promising. This review focuses on the currently available treatments for MAFLD and MASH, ongoing phase 3 clinical trials, and unresolved controversies in clinical trials in this area.https://doi.org/10.1002/poh2.96clinical trialsMAFLDresmetirom |
| spellingShingle | Cameron Gofton Jacob George Dawn of an era of effective treatments for MAFLD Portal Hypertension & Cirrhosis clinical trials MAFLD resmetirom |
| title | Dawn of an era of effective treatments for MAFLD |
| title_full | Dawn of an era of effective treatments for MAFLD |
| title_fullStr | Dawn of an era of effective treatments for MAFLD |
| title_full_unstemmed | Dawn of an era of effective treatments for MAFLD |
| title_short | Dawn of an era of effective treatments for MAFLD |
| title_sort | dawn of an era of effective treatments for mafld |
| topic | clinical trials MAFLD resmetirom |
| url | https://doi.org/10.1002/poh2.96 |
| work_keys_str_mv | AT camerongofton dawnofaneraofeffectivetreatmentsformafld AT jacobgeorge dawnofaneraofeffectivetreatmentsformafld |