Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C

Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C

Abstract Pro-inflammatory cytokines, like interleukin-1 beta and interferon gamma, are known to activate signalling pathways causing pancreatic beta cell death and dysfunction, contributing to the onset of diabetes. Targeting cytokine signalling pathways offers a potential strategy to slow or even h...

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Bibliographic Details
Main Authors: Sara Ullsten, Kine Østnes Hansen, Guillaume Axel Petit, Espen Holst Hansen, Jeanette Hammer Andersen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Diabetes
Beta cells
Proliferation
Kinase inhibition
DYRK
Cytokines
Online Access:https://doi.org/10.1038/s41598-025-85178-w
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