CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion “closed” conformation, which is targeted by broadly neutralizing antibodies (bnAbs). CD4 binding drives Env into more “ope...

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Main Authors: Jonathan Richard, Gérémy Sannier, Li Zhu, Jérémie Prévost, Lorie Marchitto, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Hongil Kim, Yaping Sun, Debashree Chatterjee, Halima Medjahed, Catherine Bourassa, Gloria-Gabrielle Delgado, Mathieu Dubé, Frank Kirchhoff, Beatrice H. Hahn, Priti Kumar, Daniel E. Kaufmann, Andrés Finzi
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
HIV-1
ADCC
Env
nnAbs
bNAbs
hu-mice
Online Access:https://journals.asm.org/doi/10.1128/mbio.01827-24
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