SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies.
<h4>Background</h4>Health personnel (HP) are on the frontlines during response to public health emergencies like COVID-19. This risk of exposure suggests the need for safety in responding to any pandemic. Therefore, to ascertain the rate of SARS-CoV-2 infection and immunity, and their de...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0304477 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841533129640116224 |
|---|---|
| author | Sen Claudine Henriette Ngomtcho Blaise Mboringong Akenji Ketina Hirma Tchio-Nighie Joseph Fokam Etienne Guenou Carolle Nsa'Amang Eyebe Yvan Junior Nzegni Kamkoum Valdex Derick Ntale Tchoffo Collins Buh Nkum Hervé Christian Tchoudjin Paho Yvette Marie Solange Ebogo Aude Nanfak Martin Maidadi-Foudi Crescence Fouda Angyiba Serge Andigema Lilian Nsah Bongdze-Em Beri Nadin Nfor Judith Torimiro Anne Cécile Zoung-Kanyi Bissek Michel Noubom Marie Claire Assoumou Okomo Jérôme Ateudjieu |
| author_facet | Sen Claudine Henriette Ngomtcho Blaise Mboringong Akenji Ketina Hirma Tchio-Nighie Joseph Fokam Etienne Guenou Carolle Nsa'Amang Eyebe Yvan Junior Nzegni Kamkoum Valdex Derick Ntale Tchoffo Collins Buh Nkum Hervé Christian Tchoudjin Paho Yvette Marie Solange Ebogo Aude Nanfak Martin Maidadi-Foudi Crescence Fouda Angyiba Serge Andigema Lilian Nsah Bongdze-Em Beri Nadin Nfor Judith Torimiro Anne Cécile Zoung-Kanyi Bissek Michel Noubom Marie Claire Assoumou Okomo Jérôme Ateudjieu |
| author_sort | Sen Claudine Henriette Ngomtcho |
| collection | DOAJ |
| description | <h4>Background</h4>Health personnel (HP) are on the frontlines during response to public health emergencies like COVID-19. This risk of exposure suggests the need for safety in responding to any pandemic. Therefore, to ascertain the rate of SARS-CoV-2 infection and immunity, and their determinants amongst HP become relevant.<h4>Methods</h4>A cross sectional health facility-based study was carried-out amongst HP in the Centre Region of Cameroon from 1st February to 30th June 2021. Characteristics and access to preventive tools were collected using face-to-face administered questionnaire. Nasopharyngeal swabs and whole blood were collected for PCR, IgG and IgM testing respectively. STATA version 17 software was used for data analysis. Determinants of COVID-19 infection were explored by estimating crude and adjusted Odd Ratio.<h4>Results</h4>Out of 510 HP reached, 458 were enrolled with mean age of 35 (±10) years. Thirty-four (7.4%) were PCR-positive to SARS-CoV-2 with 73.5% being clinicians versus 9 (26.4%) non-clinicians (p = 0.05). Sero-positivity to SARS-CoV-2 IgG/IgM was 40.2% (184/458), with 84.2% being clinicians versus 29 (15.8%) non-clinicians (p = 0.733). Amongst the 34 HP with PCR-positivity, 16 (47%) had no antibodies, while, 15 (44%) were IgG only. An estimate of HP (43.7%) had at least an evidence of PCR, IgG or IgM contact to COVID-19. Determinants of PCR-positivity was being clinical staff (AOR = 0.29, P = 0.039); and that of IgG/IgM were being non clinical staff (AOR = 0.41, p = 0.018) and regular use of face masks (AOR = 0.44, p = 0.001). HP trained on IPC (24%) were mainly from peripheral level (74.7%, p = 0.002).<h4>Conclusion</h4>Active infections were within the range of pandemic control (<10%). However, around two-fifths of participants have had contact with the virus, indicating that HP remains a population at risk of COVID-19 and other similarly-transmitted epidemic prone diseases, and also an important source of transmission. There is need of vaccine to achieve protectiveness, and optimal response also requires capacity building to improve the health system when challenged by a future pandemic. |
| format | Article |
| id | doaj-art-e5e477b4a48c44f2ba70d4f99459f0ad |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e5e477b4a48c44f2ba70d4f99459f0ad2025-01-17T05:32:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01195e030447710.1371/journal.pone.0304477SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies.Sen Claudine Henriette NgomtchoBlaise Mboringong AkenjiKetina Hirma Tchio-NighieJoseph FokamEtienne GuenouCarolle Nsa'Amang EyebeYvan Junior Nzegni KamkoumValdex Derick Ntale TchoffoCollins Buh NkumHervé Christian Tchoudjin PahoYvette Marie Solange EbogoAude NanfakMartin Maidadi-FoudiCrescence FoudaAngyiba Serge AndigemaLilian Nsah Bongdze-EmBeri Nadin NforJudith TorimiroAnne Cécile Zoung-Kanyi BissekMichel NoubomMarie Claire Assoumou OkomoJérôme Ateudjieu<h4>Background</h4>Health personnel (HP) are on the frontlines during response to public health emergencies like COVID-19. This risk of exposure suggests the need for safety in responding to any pandemic. Therefore, to ascertain the rate of SARS-CoV-2 infection and immunity, and their determinants amongst HP become relevant.<h4>Methods</h4>A cross sectional health facility-based study was carried-out amongst HP in the Centre Region of Cameroon from 1st February to 30th June 2021. Characteristics and access to preventive tools were collected using face-to-face administered questionnaire. Nasopharyngeal swabs and whole blood were collected for PCR, IgG and IgM testing respectively. STATA version 17 software was used for data analysis. Determinants of COVID-19 infection were explored by estimating crude and adjusted Odd Ratio.<h4>Results</h4>Out of 510 HP reached, 458 were enrolled with mean age of 35 (±10) years. Thirty-four (7.4%) were PCR-positive to SARS-CoV-2 with 73.5% being clinicians versus 9 (26.4%) non-clinicians (p = 0.05). Sero-positivity to SARS-CoV-2 IgG/IgM was 40.2% (184/458), with 84.2% being clinicians versus 29 (15.8%) non-clinicians (p = 0.733). Amongst the 34 HP with PCR-positivity, 16 (47%) had no antibodies, while, 15 (44%) were IgG only. An estimate of HP (43.7%) had at least an evidence of PCR, IgG or IgM contact to COVID-19. Determinants of PCR-positivity was being clinical staff (AOR = 0.29, P = 0.039); and that of IgG/IgM were being non clinical staff (AOR = 0.41, p = 0.018) and regular use of face masks (AOR = 0.44, p = 0.001). HP trained on IPC (24%) were mainly from peripheral level (74.7%, p = 0.002).<h4>Conclusion</h4>Active infections were within the range of pandemic control (<10%). However, around two-fifths of participants have had contact with the virus, indicating that HP remains a population at risk of COVID-19 and other similarly-transmitted epidemic prone diseases, and also an important source of transmission. There is need of vaccine to achieve protectiveness, and optimal response also requires capacity building to improve the health system when challenged by a future pandemic.https://doi.org/10.1371/journal.pone.0304477 |
| spellingShingle | Sen Claudine Henriette Ngomtcho Blaise Mboringong Akenji Ketina Hirma Tchio-Nighie Joseph Fokam Etienne Guenou Carolle Nsa'Amang Eyebe Yvan Junior Nzegni Kamkoum Valdex Derick Ntale Tchoffo Collins Buh Nkum Hervé Christian Tchoudjin Paho Yvette Marie Solange Ebogo Aude Nanfak Martin Maidadi-Foudi Crescence Fouda Angyiba Serge Andigema Lilian Nsah Bongdze-Em Beri Nadin Nfor Judith Torimiro Anne Cécile Zoung-Kanyi Bissek Michel Noubom Marie Claire Assoumou Okomo Jérôme Ateudjieu SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies. PLoS ONE |
| title | SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies. |
| title_full | SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies. |
| title_fullStr | SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies. |
| title_full_unstemmed | SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies. |
| title_short | SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencies. |
| title_sort | sars cov 2 active infection and antibodies amongst health personnel during the outbreak in cameroon strengthening the health system for response to future public health emergencies |
| url | https://doi.org/10.1371/journal.pone.0304477 |
| work_keys_str_mv | AT senclaudinehenriettengomtcho sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT blaisemboringongakenji sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT ketinahirmatchionighie sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT josephfokam sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT etienneguenou sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT carollensaamangeyebe sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT yvanjuniornzegnikamkoum sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT valdexderickntaletchoffo sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT collinsbuhnkum sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT hervechristiantchoudjinpaho sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT yvettemariesolangeebogo sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT audenanfak sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT martinmaidadifoudi sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT crescencefouda sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT angyibasergeandigema sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT liliannsahbongdzeem sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT berinadinnfor sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT judithtorimiro sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT annececilezoungkanyibissek sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT michelnoubom sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT marieclaireassoumouokomo sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies AT jeromeateudjieu sarscov2activeinfectionandantibodiesamongsthealthpersonnelduringtheoutbreakincameroonstrengtheningthehealthsystemforresponsetofuturepublichealthemergencies |