Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology
In vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomime...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424001135 |
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| _version_ | 1846148988980428800 |
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| author | Yusuke Nishimura |
| author_facet | Yusuke Nishimura |
| author_sort | Yusuke Nishimura |
| collection | DOAJ |
| description | In vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomimetic systems, such as organ-on-a-chip, which is based on microfluidic device technology, to serve as an in vitro model for the kidney. These systems aimed to recreate a physiological cultivation environment. This review has provided an overview of organ-on-a-chip research focused on glomeruli and tubules as in vitro models for the kidney and discusses future prospects. |
| format | Article |
| id | doaj-art-e5dc785996814f6b993b102fc7919e7c |
| institution | Kabale University |
| issn | 2352-3204 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-e5dc785996814f6b993b102fc7919e7c2024-11-30T07:10:48ZengElsevierRegenerative Therapy2352-32042024-06-0126275280Revolutionizing renal research: The future of kidney-on-a-chip in biotechnologyYusuke Nishimura0Department of Clinical Engineering, Faculty of Medical Science and Technology, Gunma Paz University, 3-3-4 Tonyamachi, Takasaki-shi, Gunma, 370-0006, JapanIn vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomimetic systems, such as organ-on-a-chip, which is based on microfluidic device technology, to serve as an in vitro model for the kidney. These systems aimed to recreate a physiological cultivation environment. This review has provided an overview of organ-on-a-chip research focused on glomeruli and tubules as in vitro models for the kidney and discusses future prospects.http://www.sciencedirect.com/science/article/pii/S2352320424001135Organ-on-a-chipRenal tubuleGlomerulusMicrofluidic deviceShear stress |
| spellingShingle | Yusuke Nishimura Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology Regenerative Therapy Organ-on-a-chip Renal tubule Glomerulus Microfluidic device Shear stress |
| title | Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology |
| title_full | Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology |
| title_fullStr | Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology |
| title_full_unstemmed | Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology |
| title_short | Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology |
| title_sort | revolutionizing renal research the future of kidney on a chip in biotechnology |
| topic | Organ-on-a-chip Renal tubule Glomerulus Microfluidic device Shear stress |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424001135 |
| work_keys_str_mv | AT yusukenishimura revolutionizingrenalresearchthefutureofkidneyonachipinbiotechnology |