Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense
Unlike most plants, members of the genus Solanum produce cholesterol and use this as a precursor for steroidal glycoalkaloids. The production of the compounds begins as a branch from brassinosteroid biosynthesis, which produces cholesterol that is further modified to produce steroidal glycoalkaloids...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Horticultural Plant Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468014124000013 |
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| author | Vincenzo Averello, IV Adrian D. Hegeman Changbin Chen |
| author_facet | Vincenzo Averello, IV Adrian D. Hegeman Changbin Chen |
| author_sort | Vincenzo Averello, IV |
| collection | DOAJ |
| description | Unlike most plants, members of the genus Solanum produce cholesterol and use this as a precursor for steroidal glycoalkaloids. The production of the compounds begins as a branch from brassinosteroid biosynthesis, which produces cholesterol that is further modified to produce steroidal glycoalkaloids. During the cholesterol biosynthesis pathway, genetic engineering could alter the formation of cholesterol from provitamin D3 (7-dehydrocholesterol) and produce vitamin D3. Cholesterol is a precursor for many steroidal glycoalkaloids, including α-tomatine and esculeoside A. Alpha-tomatine is consumed by mammals and it can reduce cholesterol content and improve LDL:HDL ratio. When there is a high α-tomatine content, the fruit will have a bitter flavor, which together with other steroidal glycoalkaloids serving as protective and defensive compounds for tomato against insect, fungal, and bacterial pests. These compounds also affect the rhizosphere bacteria by recruiting beneficial bacteria. One of the steroidal glycoalkaloids, esculeoside A increases while fruit ripening. This review focuses on recent studies that uncovered key reactions of the production of cholesterol and steroidal glycoalkaloids in tomato connecting to human health, fruit flavor, and plant defense and the potential application for tomato crop improvement. |
| format | Article |
| id | doaj-art-e5bb98d482894018aa3f3cc78b6fec4d |
| institution | Kabale University |
| issn | 2468-0141 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Horticultural Plant Journal |
| spelling | doaj-art-e5bb98d482894018aa3f3cc78b6fec4d2025-01-01T05:10:57ZengKeAi Communications Co., Ltd.Horticultural Plant Journal2468-01412025-01-011114256Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defenseVincenzo Averello, IV0Adrian D. Hegeman1Changbin Chen2Department of Horticultural Science, University of Minnesota, 1970 Folwell Avenue, St. Paul, MN 55108, USADepartment of Horticultural Science, University of Minnesota, 1970 Folwell Avenue, St. Paul, MN 55108, USA; Corresponding authors.Department of Horticultural Science, University of Minnesota, 1970 Folwell Avenue, St. Paul, MN 55108, USA; School of Life Sciences, Arizona State University, 427 E Tyler Mall, Tempe, AZ 85287, USA; Corresponding authors.Unlike most plants, members of the genus Solanum produce cholesterol and use this as a precursor for steroidal glycoalkaloids. The production of the compounds begins as a branch from brassinosteroid biosynthesis, which produces cholesterol that is further modified to produce steroidal glycoalkaloids. During the cholesterol biosynthesis pathway, genetic engineering could alter the formation of cholesterol from provitamin D3 (7-dehydrocholesterol) and produce vitamin D3. Cholesterol is a precursor for many steroidal glycoalkaloids, including α-tomatine and esculeoside A. Alpha-tomatine is consumed by mammals and it can reduce cholesterol content and improve LDL:HDL ratio. When there is a high α-tomatine content, the fruit will have a bitter flavor, which together with other steroidal glycoalkaloids serving as protective and defensive compounds for tomato against insect, fungal, and bacterial pests. These compounds also affect the rhizosphere bacteria by recruiting beneficial bacteria. One of the steroidal glycoalkaloids, esculeoside A increases while fruit ripening. This review focuses on recent studies that uncovered key reactions of the production of cholesterol and steroidal glycoalkaloids in tomato connecting to human health, fruit flavor, and plant defense and the potential application for tomato crop improvement.http://www.sciencedirect.com/science/article/pii/S2468014124000013CholesterolSteroidal glycoalkaloidsTomatoBiosynthesisα-tomatineSterols |
| spellingShingle | Vincenzo Averello, IV Adrian D. Hegeman Changbin Chen Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense Horticultural Plant Journal Cholesterol Steroidal glycoalkaloids Tomato Biosynthesis α-tomatine Sterols |
| title | Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense |
| title_full | Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense |
| title_fullStr | Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense |
| title_full_unstemmed | Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense |
| title_short | Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato (Solanum lycopersicum L.) for human health, fruit flavor, and plant defense |
| title_sort | finding the balance modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato solanum lycopersicum l for human health fruit flavor and plant defense |
| topic | Cholesterol Steroidal glycoalkaloids Tomato Biosynthesis α-tomatine Sterols |
| url | http://www.sciencedirect.com/science/article/pii/S2468014124000013 |
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