Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials
Mortality and morbidity of cardiovascular diseases (CVDs) including ischemic heart disease (IHD) and heart failure (HF) are arising worldwide. Once cardiomyocyte is impaired, it is challenging to regenerate which is largely limited by the irreversibility of cell cycle after birth. Emergent approache...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041722000051 |
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| author | Xuerui Chen Liyun Zhu Jianyun Liu Yi Lu Longlu Pan Junjie Xiao |
| author_facet | Xuerui Chen Liyun Zhu Jianyun Liu Yi Lu Longlu Pan Junjie Xiao |
| author_sort | Xuerui Chen |
| collection | DOAJ |
| description | Mortality and morbidity of cardiovascular diseases (CVDs) including ischemic heart disease (IHD) and heart failure (HF) are arising worldwide. Once cardiomyocyte is impaired, it is challenging to regenerate which is largely limited by the irreversibility of cell cycle after birth. Emergent approaches in regenerative medicine head toward the application of extracellular vesicles (EVs) such as exosomes in next-generation cell-free treatment strategies for CVDs, attributed to their repair promotion. However, naked exosomes undergo major obstacles of high clearance by the mononuclear phagocyte system and transient retention of exosomes in transplanted areas, eventually failing in the endogenous repair. Strategies optimizing matrix materials to release exosomes in a targeted, sustained and minimally invasive manner will pave the way for empowering cardiac repair and regeneration. In this review, we extensively summarize the integrated devices of exosome or exosome-like nanovectors with biomaterials for treating CVDs. Furthermore, we provide recommendations on how combinations of exosomes/ biomaterials (e.g. hydrogels, stents, cell sheets, cardiac patches, microneedles, spray and 3D tissue matrix) increase the success rate of cell-free therapies which will boost cardiac repair and regeneration in the clinical settings of CVDs. |
| format | Article |
| id | doaj-art-e5af2df914c74c9aba9cb1dee60067d8 |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-e5af2df914c74c9aba9cb1dee60067d82024-11-23T06:34:48ZengElsevierExtracellular Vesicle2773-04172022-12-011100010Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materialsXuerui Chen0Liyun Zhu1Jianyun Liu2Yi Lu3Longlu Pan4Junjie Xiao5Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, ChinaInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, ChinaInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, ChinaInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, ChinaInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, ChinaInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, China; Corresponding author at: Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.Mortality and morbidity of cardiovascular diseases (CVDs) including ischemic heart disease (IHD) and heart failure (HF) are arising worldwide. Once cardiomyocyte is impaired, it is challenging to regenerate which is largely limited by the irreversibility of cell cycle after birth. Emergent approaches in regenerative medicine head toward the application of extracellular vesicles (EVs) such as exosomes in next-generation cell-free treatment strategies for CVDs, attributed to their repair promotion. However, naked exosomes undergo major obstacles of high clearance by the mononuclear phagocyte system and transient retention of exosomes in transplanted areas, eventually failing in the endogenous repair. Strategies optimizing matrix materials to release exosomes in a targeted, sustained and minimally invasive manner will pave the way for empowering cardiac repair and regeneration. In this review, we extensively summarize the integrated devices of exosome or exosome-like nanovectors with biomaterials for treating CVDs. Furthermore, we provide recommendations on how combinations of exosomes/ biomaterials (e.g. hydrogels, stents, cell sheets, cardiac patches, microneedles, spray and 3D tissue matrix) increase the success rate of cell-free therapies which will boost cardiac repair and regeneration in the clinical settings of CVDs.http://www.sciencedirect.com/science/article/pii/S2773041722000051ExosomesBiomaterialsCardiac repairCell-free therapyCardiovascular diseases |
| spellingShingle | Xuerui Chen Liyun Zhu Jianyun Liu Yi Lu Longlu Pan Junjie Xiao Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials Extracellular Vesicle Exosomes Biomaterials Cardiac repair Cell-free therapy Cardiovascular diseases |
| title | Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials |
| title_full | Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials |
| title_fullStr | Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials |
| title_full_unstemmed | Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials |
| title_short | Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials |
| title_sort | greasing wheels of cell free therapies for cardiovascular diseases integrated devices of exosomes exosome like nanovectors with bioinspired materials |
| topic | Exosomes Biomaterials Cardiac repair Cell-free therapy Cardiovascular diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2773041722000051 |
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