Highly multiplexed design of an allosteric transcription factor to sense new ligands

Highly multiplexed design of an allosteric transcription factor to sense new ligands

Abstract Allosteric transcription factors (aTF) regulate gene expression through conformational changes induced by small molecule binding. Although widely used as biosensors, aTFs have proven challenging to design for detecting new molecules because mutation of ligand-binding residues often disrupts...

Full description

Saved in:
Bibliographic Details
Main Authors: Kyle K. Nishikawa, Jackie Chen, Justin F. Acheson, Svetlana V. Harbaugh, Phil Huss, Max Frenkel, Nathan Novy, Hailey R. Sieren, Ella C. Lodewyk, Daniel H. Lee, Jorge L. Chávez, Brian G. Fox, Srivatsan Raman
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54260-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-024-54260-8

Similar Items