The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers
Ethoxyquin (EQ) is a widely used feed additives for aquaculture, but the potential hazard to fish and consumers are not fully understood. In this work, EQ was applied to tilapia fed with either high-fat or low-fat feed, and the changes in growth performance and intestinal barrier integrality of gene...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250010 |
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| author | Shanjun Chen Chong Wang Yanan Liu Zhigang Zhou Linglin Fu Yanbo Wang |
| author_facet | Shanjun Chen Chong Wang Yanan Liu Zhigang Zhou Linglin Fu Yanbo Wang |
| author_sort | Shanjun Chen |
| collection | DOAJ |
| description | Ethoxyquin (EQ) is a widely used feed additives for aquaculture, but the potential hazard to fish and consumers are not fully understood. In this work, EQ was applied to tilapia fed with either high-fat or low-fat feed, and the changes in growth performance and intestinal barrier integrality of genetically improved farmed tilapia was observed. Additionally, the microbiota in the intestinal content and flesh was analyzed by 16S rDNA sequencing, and the flesh metabolites was measured by LC-MS/MS untargeted metabolomics. In the low-fat group, EQ increased weight gain and feed conversion rate, but reduced survival rate. In the high-fat group, only weight gain decreased, and there was no significant effect on feed conversion rate and survival rate. Additionally, the intestinal villi and microbiota diversity was impaired in both feeding conditions. Microbiota analysis revealed that EQ resulted in different composition and lower diversity of the flesh microbiota and upregulated the proportion of potential pathogens. EQ also changed the flesh metabolome, decreasing beneficial metabolites and increasing potential harmful components. This work elucidated the effect of EQ on growth performance of tilapia and implied that it has adverse effects on tilapia and may be passed on to consumers. |
| format | Article |
| id | doaj-art-e573aa55af6d43349aa83f44510ba9ee |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-e573aa55af6d43349aa83f44510ba9ee2025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363236324410.26599/FSHW.2023.9250010The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumersShanjun Chen0Chong Wang1Yanan Liu2Zhigang Zhou3Linglin Fu4Yanbo Wang5Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaSino-Norway Joint Lab on Fish Gut Microbiota, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, ChinaEthoxyquin (EQ) is a widely used feed additives for aquaculture, but the potential hazard to fish and consumers are not fully understood. In this work, EQ was applied to tilapia fed with either high-fat or low-fat feed, and the changes in growth performance and intestinal barrier integrality of genetically improved farmed tilapia was observed. Additionally, the microbiota in the intestinal content and flesh was analyzed by 16S rDNA sequencing, and the flesh metabolites was measured by LC-MS/MS untargeted metabolomics. In the low-fat group, EQ increased weight gain and feed conversion rate, but reduced survival rate. In the high-fat group, only weight gain decreased, and there was no significant effect on feed conversion rate and survival rate. Additionally, the intestinal villi and microbiota diversity was impaired in both feeding conditions. Microbiota analysis revealed that EQ resulted in different composition and lower diversity of the flesh microbiota and upregulated the proportion of potential pathogens. EQ also changed the flesh metabolome, decreasing beneficial metabolites and increasing potential harmful components. This work elucidated the effect of EQ on growth performance of tilapia and implied that it has adverse effects on tilapia and may be passed on to consumers.https://www.sciopen.com/article/10.26599/FSHW.2023.9250010ethoxyquintilapiafeedmicrobiotametabolome |
| spellingShingle | Shanjun Chen Chong Wang Yanan Liu Zhigang Zhou Linglin Fu Yanbo Wang The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers Food Science and Human Wellness ethoxyquin tilapia feed microbiota metabolome |
| title | The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers |
| title_full | The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers |
| title_fullStr | The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers |
| title_full_unstemmed | The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers |
| title_short | The effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers |
| title_sort | effect of feed additive ethoxyquin on tilapia growth performance and potential secondary hazard to consumers |
| topic | ethoxyquin tilapia feed microbiota metabolome |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250010 |
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