Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke
Abstract Background Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-024-00931-8 |
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| author | AbdelRahman Mohamed Hussein Iman Mohamed Bayoumy Khaled Ossama Abdulghani Mona Ali Eissa Ehab Mostafa Ahmed Ali Ahmed Abou Elmaaty |
| author_facet | AbdelRahman Mohamed Hussein Iman Mohamed Bayoumy Khaled Ossama Abdulghani Mona Ali Eissa Ehab Mostafa Ahmed Ali Ahmed Abou Elmaaty |
| author_sort | AbdelRahman Mohamed Hussein |
| collection | DOAJ |
| description | Abstract Background Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome following IV rt-PA treatment in a group of Egyptian patients with acute ischemic stroke (AIS). We included sixty patients diagnosed with AIS who met the criteria for IV rt-PA therapy. Data were collected and statistically analyzed, we established correlations with functional outcomes as measured by the modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS) 3-month post-treatment. Results Of the 60 patients, 40 (66.67%) exhibited a favorable functional outcome, while 20 (33.33%) experienced a less favorable outcome. Poor functional outcome was associated with atrial fibrillation [p value < 0.001, odds ratio (OR) 6.28], hypertension (p value = 0.001, OR 3.65), diabetes mellitus (p value 0.009, OR 2.805), and a higher NIHSS at admission (p value = 0.003, OR 8.03). Conclusions Certain factors may affect functional outcome in stroke patients treated with rt-PA therapy. There are strong associations between hypertension, diabetes, atrial fibrillation, post-rt-PA intracerebral hemorrhage (both asymptomatic and symptomatic), specific stroke subtypes, and less favorable functional outcome 3 months after rt-PA administration, as measured by the mRS. |
| format | Article |
| id | doaj-art-e5470ddb302747f29162f11de94e5e28 |
| institution | Kabale University |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-e5470ddb302747f29162f11de94e5e282025-01-12T12:12:21ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-01-016111710.1186/s41983-024-00931-8Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic strokeAbdelRahman Mohamed Hussein0Iman Mohamed Bayoumy1Khaled Ossama Abdulghani2Mona Ali Eissa3Ehab Mostafa Ahmed4Ali Ahmed Abou Elmaaty5Department of Neurology, Nasr City Insurance HospitalDepartment of Neurology, Faculty of Medicine, Helwan UniversityDepartment of Neurology, Faculty of Medicine, Helwan UniversityDepartment of Neurology, Faculty of Medicine, Helwan UniversityDepartment of Neurology, Faculty of Medicine, Helwan UniversityDepartment of Neurology, Faculty of Medicine, Helwan UniversityAbstract Background Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome following IV rt-PA treatment in a group of Egyptian patients with acute ischemic stroke (AIS). We included sixty patients diagnosed with AIS who met the criteria for IV rt-PA therapy. Data were collected and statistically analyzed, we established correlations with functional outcomes as measured by the modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS) 3-month post-treatment. Results Of the 60 patients, 40 (66.67%) exhibited a favorable functional outcome, while 20 (33.33%) experienced a less favorable outcome. Poor functional outcome was associated with atrial fibrillation [p value < 0.001, odds ratio (OR) 6.28], hypertension (p value = 0.001, OR 3.65), diabetes mellitus (p value 0.009, OR 2.805), and a higher NIHSS at admission (p value = 0.003, OR 8.03). Conclusions Certain factors may affect functional outcome in stroke patients treated with rt-PA therapy. There are strong associations between hypertension, diabetes, atrial fibrillation, post-rt-PA intracerebral hemorrhage (both asymptomatic and symptomatic), specific stroke subtypes, and less favorable functional outcome 3 months after rt-PA administration, as measured by the mRS.https://doi.org/10.1186/s41983-024-00931-8StrokeRt-PANIHSSmRSThrombolysis functional outcome |
| spellingShingle | AbdelRahman Mohamed Hussein Iman Mohamed Bayoumy Khaled Ossama Abdulghani Mona Ali Eissa Ehab Mostafa Ahmed Ali Ahmed Abou Elmaaty Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Stroke Rt-PA NIHSS mRS Thrombolysis functional outcome |
| title | Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke |
| title_full | Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke |
| title_fullStr | Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke |
| title_full_unstemmed | Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke |
| title_short | Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke |
| title_sort | predictors of clinical outcome in post thrombolysis among sample of egyptian patients with acute ischemic stroke |
| topic | Stroke Rt-PA NIHSS mRS Thrombolysis functional outcome |
| url | https://doi.org/10.1186/s41983-024-00931-8 |
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