Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome
Background: Obstructive sleep apnoea syndrome (OSAS) is an independent risk factor for cardiovascular morbidity and mortality and has a detrimental effect on vascular function, in particular on arterial stiffness and endothelial function. Continuous positive airway pressure (CPAP) is the gold-standa...
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2024-11-01
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| author | Mara Volpentesta Valentino Condoleo Alberto Panza Giandomenico Severini Luca Soraci Cataldo Rotondo Giuseppe Armentaro Corrado Pelaia Vanessa Teresa Fiorentino Francesco Andreozzi Giorgio Sesti Andrea Corsonello Angela Sciacqua |
| author_facet | Mara Volpentesta Valentino Condoleo Alberto Panza Giandomenico Severini Luca Soraci Cataldo Rotondo Giuseppe Armentaro Corrado Pelaia Vanessa Teresa Fiorentino Francesco Andreozzi Giorgio Sesti Andrea Corsonello Angela Sciacqua |
| author_sort | Mara Volpentesta |
| collection | DOAJ |
| description | Background: Obstructive sleep apnoea syndrome (OSAS) is an independent risk factor for cardiovascular morbidity and mortality and has a detrimental effect on vascular function, in particular on arterial stiffness and endothelial function. Continuous positive airway pressure (CPAP) is the gold-standard therapy for OSAS and its effects on arterial stiffness and endothelial function have been demonstrated in non-elderly patients. Objectives: The objective of this study was to evaluate the effect of one year of CPAP treatment on arterial stiffness, through assessment of carotid–femoral pulse wave velocity (cf-PWV), and on endothelial function, through the reactive hyperaemia index (RHi), in a real-life cohort of elderly patients with moderate-to-severe OSAS and several comorbidities. Methods: In this nonrandomised prospective study, we enrolled 469 consecutive elderly patients affected by moderate-to-severe OSAS distributed in two groups: CPAP-treated (<i>n</i> = 225) and untreated patients (<i>n</i> = 244). Results: At one-year follow-up, in the treated group emerged an important improvement in poligraphics (AHI, ODI, TC90, mean SpO<sub>2</sub>%), laboratory (HOMA index, eGFR, hs-CRP) and vascular function parameters: cf-PWV. The stepwise multivariate linear regression demonstrated a significant correlation between the delta of the polygraph parameters and the delta of PWV and RHi. Conclusions: Our study confirmed the favourable effects of CPAP therapy in a cohort of elderly patients affected by OSAS and several comorbidities on sleep respiratory parameters and vascular function; early diagnosis and treatment with CPAP might be beneficial to delay or prevent the occurrence of cardiovascular events in these groups of patients. |
| format | Article |
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| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-e52b9b5b33914bde8dae9204d9d37b6e2024-11-26T17:53:14ZengMDPI AGBiomedicines2227-90592024-11-011211256310.3390/biomedicines12112563Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea SyndromeMara Volpentesta0Valentino Condoleo1Alberto Panza2Giandomenico Severini3Luca Soraci4Cataldo Rotondo5Giuseppe Armentaro6Corrado Pelaia7Vanessa Teresa Fiorentino8Francesco Andreozzi9Giorgio Sesti10Andrea Corsonello11Angela Sciacqua12Unit of Geriatric Medicine, IRCCS INRCA, 87100 Cosenza, ItalyGeriatrics Division, University Hospital “R. Dulbecco”, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyUnit of Geriatric Medicine, IRCCS INRCA, 87100 Cosenza, ItalyCoordinamento Medico legale, Istituto Nazionale della Previdenza Sociale, 88100 Catanzaro, ItalyGeriatrics Division, University Hospital “R. Dulbecco”, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Clinical and Molecular Medicine, University of Rome-Sapienza, 00185 Rome, ItalyUnit of Geriatric Medicine, IRCCS INRCA, 87100 Cosenza, ItalyGeriatrics Division, University Hospital “R. Dulbecco”, 88100 Catanzaro, ItalyBackground: Obstructive sleep apnoea syndrome (OSAS) is an independent risk factor for cardiovascular morbidity and mortality and has a detrimental effect on vascular function, in particular on arterial stiffness and endothelial function. Continuous positive airway pressure (CPAP) is the gold-standard therapy for OSAS and its effects on arterial stiffness and endothelial function have been demonstrated in non-elderly patients. Objectives: The objective of this study was to evaluate the effect of one year of CPAP treatment on arterial stiffness, through assessment of carotid–femoral pulse wave velocity (cf-PWV), and on endothelial function, through the reactive hyperaemia index (RHi), in a real-life cohort of elderly patients with moderate-to-severe OSAS and several comorbidities. Methods: In this nonrandomised prospective study, we enrolled 469 consecutive elderly patients affected by moderate-to-severe OSAS distributed in two groups: CPAP-treated (<i>n</i> = 225) and untreated patients (<i>n</i> = 244). Results: At one-year follow-up, in the treated group emerged an important improvement in poligraphics (AHI, ODI, TC90, mean SpO<sub>2</sub>%), laboratory (HOMA index, eGFR, hs-CRP) and vascular function parameters: cf-PWV. The stepwise multivariate linear regression demonstrated a significant correlation between the delta of the polygraph parameters and the delta of PWV and RHi. Conclusions: Our study confirmed the favourable effects of CPAP therapy in a cohort of elderly patients affected by OSAS and several comorbidities on sleep respiratory parameters and vascular function; early diagnosis and treatment with CPAP might be beneficial to delay or prevent the occurrence of cardiovascular events in these groups of patients.https://www.mdpi.com/2227-9059/12/11/2563CPAPelderlyOSASarterial stiffnessendothelial dysfunction |
| spellingShingle | Mara Volpentesta Valentino Condoleo Alberto Panza Giandomenico Severini Luca Soraci Cataldo Rotondo Giuseppe Armentaro Corrado Pelaia Vanessa Teresa Fiorentino Francesco Andreozzi Giorgio Sesti Andrea Corsonello Angela Sciacqua Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome Biomedicines CPAP elderly OSAS arterial stiffness endothelial dysfunction |
| title | Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome |
| title_full | Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome |
| title_fullStr | Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome |
| title_full_unstemmed | Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome |
| title_short | Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome |
| title_sort | effects of continuous positive airway pressure treatment on vascular function in a real life cohort of elderly patients with obstructive sleep apnoea syndrome |
| topic | CPAP elderly OSAS arterial stiffness endothelial dysfunction |
| url | https://www.mdpi.com/2227-9059/12/11/2563 |
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