Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea
This study aims to use hot aqueous extract of herbal residue (HRE) to enhance bacterial growth and possess anti-diarrheal effects. In this study, lactobacillus species L. brevis (SAM-1), Lactobacillus plantarum (SAM-2), and Lactobacillus herbinensis (SAM-3) were isolated from date palm sap (collecte...
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Elsevier
2024-12-01
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| Series: | Food Hydrocolloids for Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025924000062 |
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| author | Samima Yeasmin Abu Naser Md Nayeem Anjumanara khatun ABM Ashraful Muhsi Faiaz Shumaia Parvin Most. Afia Akhtar Md Aziz Abdur Rahman Md Abu Reza Athanasios Alexiou Marios Papadakis Nermeen N. Welson Mohamed H. Mahmoud Gaber El-Saber Batiha Ronok Zahan |
| author_facet | Samima Yeasmin Abu Naser Md Nayeem Anjumanara khatun ABM Ashraful Muhsi Faiaz Shumaia Parvin Most. Afia Akhtar Md Aziz Abdur Rahman Md Abu Reza Athanasios Alexiou Marios Papadakis Nermeen N. Welson Mohamed H. Mahmoud Gaber El-Saber Batiha Ronok Zahan |
| author_sort | Samima Yeasmin |
| collection | DOAJ |
| description | This study aims to use hot aqueous extract of herbal residue (HRE) to enhance bacterial growth and possess anti-diarrheal effects. In this study, lactobacillus species L. brevis (SAM-1), Lactobacillus plantarum (SAM-2), and Lactobacillus herbinensis (SAM-3) were isolated from date palm sap (collected in winter season). Square Pharmaceuticals PLC, Bangladesh provided herbal residues ‘Adovas’ which is non-sedating herbal cough syrup with sixteen common herbs including Adhatoda vasica. In our observation, HRE increased the number of colonies in MRS media. In the anti-diarrheal study by castor oil and magnesium sulphate-induced diarrheal mouse model, SAM-1 and 2 with or without HRE showed almost similar results. After initial morphological characterization, tests such as resistance to low pH, bile salt and survival capability in gastric simulated fluid (GSF) were performed to confirm them as a probiotic candidate. All three isolates were gram-positive bacteria and could grow in a mesophilic range of temperatures. The isolates were catalase-negative and were able to coagulate milk after overnight incubation. As the isolates exhibited resistance to low pH and could tolerate bile salts, they may survive in the stomach and intestine, thus making them a promising probiotic candidate. The isolated probiotics and HRE inhibited diarrheal and restored the body's electrolytes. Interestingly, SAM-2 showed higher efficacy than the standard drug (Loperamide), while SAM-1 showed a similar effect and SAM-3, had less effect than Loperamide. The findings suggest that probiotics and herbal residue could contribute to diarrhoeal disease prevention, which might be an alternative to a synthetic standard drug (Loperamide). |
| format | Article |
| id | doaj-art-e52b8c0cdfa346f8a422aba0aa5c99b2 |
| institution | Kabale University |
| issn | 2667-0259 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj-art-e52b8c0cdfa346f8a422aba0aa5c99b22024-12-17T05:01:38ZengElsevierFood Hydrocolloids for Health2667-02592024-12-016100181Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrheaSamima Yeasmin0Abu Naser Md Nayeem1Anjumanara khatun2ABM Ashraful3Muhsi Faiaz4Shumaia Parvin5Most. Afia Akhtar6Md Aziz Abdur Rahman7Md Abu Reza8Athanasios Alexiou9Marios Papadakis10Nermeen N. Welson11Mohamed H. Mahmoud12Gaber El-Saber Batiha13Ronok Zahan14Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi 6205, BangladeshUniversity Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India; Department of Research & Development, Funogen, Athens, 11741, Greece; Department of Research & Development, AFNP Med, Wien 1030, Austria; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW 2770, AustraliaDepartment of Surgery II, University Hospital Witten-Herdecke, Heusnerstrasse 40, University of Witten-Herdecke, 42283, Wuppertal, Germany; Corresponding author.Department of Forensic medicine and clinical toxicology, Faculty of Medicine, Beni-Suef University, 62511 Beni Suef, EgyptDepartment of Biochemistry, college of science, King Saud University, Kingdom of Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, EgyptDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi 6205, BangladeshThis study aims to use hot aqueous extract of herbal residue (HRE) to enhance bacterial growth and possess anti-diarrheal effects. In this study, lactobacillus species L. brevis (SAM-1), Lactobacillus plantarum (SAM-2), and Lactobacillus herbinensis (SAM-3) were isolated from date palm sap (collected in winter season). Square Pharmaceuticals PLC, Bangladesh provided herbal residues ‘Adovas’ which is non-sedating herbal cough syrup with sixteen common herbs including Adhatoda vasica. In our observation, HRE increased the number of colonies in MRS media. In the anti-diarrheal study by castor oil and magnesium sulphate-induced diarrheal mouse model, SAM-1 and 2 with or without HRE showed almost similar results. After initial morphological characterization, tests such as resistance to low pH, bile salt and survival capability in gastric simulated fluid (GSF) were performed to confirm them as a probiotic candidate. All three isolates were gram-positive bacteria and could grow in a mesophilic range of temperatures. The isolates were catalase-negative and were able to coagulate milk after overnight incubation. As the isolates exhibited resistance to low pH and could tolerate bile salts, they may survive in the stomach and intestine, thus making them a promising probiotic candidate. The isolated probiotics and HRE inhibited diarrheal and restored the body's electrolytes. Interestingly, SAM-2 showed higher efficacy than the standard drug (Loperamide), while SAM-1 showed a similar effect and SAM-3, had less effect than Loperamide. The findings suggest that probiotics and herbal residue could contribute to diarrhoeal disease prevention, which might be an alternative to a synthetic standard drug (Loperamide).http://www.sciencedirect.com/science/article/pii/S2667025924000062Herb residueDate palm sapProbioticsLactobacillus brevisLactobacillus plantarumLactobacillus herbinensis |
| spellingShingle | Samima Yeasmin Abu Naser Md Nayeem Anjumanara khatun ABM Ashraful Muhsi Faiaz Shumaia Parvin Most. Afia Akhtar Md Aziz Abdur Rahman Md Abu Reza Athanasios Alexiou Marios Papadakis Nermeen N. Welson Mohamed H. Mahmoud Gaber El-Saber Batiha Ronok Zahan Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea Food Hydrocolloids for Health Herb residue Date palm sap Probiotics Lactobacillus brevis Lactobacillus plantarum Lactobacillus herbinensis |
| title | Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea |
| title_full | Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea |
| title_fullStr | Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea |
| title_full_unstemmed | Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea |
| title_short | Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea |
| title_sort | re processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea |
| topic | Herb residue Date palm sap Probiotics Lactobacillus brevis Lactobacillus plantarum Lactobacillus herbinensis |
| url | http://www.sciencedirect.com/science/article/pii/S2667025924000062 |
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