Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics
Cancer continues to be one of the leading causes of death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, and surgery have limitations. RNA therapy and cancer vaccines hold considerable promise as an alternative to conventional therapies for their ability to ena...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1499474/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525891097690112 |
|---|---|
| author | Olga V. Sergeeva Liang Luo Anthony Guiseppi-Elie Anthony Guiseppi-Elie Anthony Guiseppi-Elie |
| author_facet | Olga V. Sergeeva Liang Luo Anthony Guiseppi-Elie Anthony Guiseppi-Elie Anthony Guiseppi-Elie |
| author_sort | Olga V. Sergeeva |
| collection | DOAJ |
| description | Cancer continues to be one of the leading causes of death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, and surgery have limitations. RNA therapy and cancer vaccines hold considerable promise as an alternative to conventional therapies for their ability to enable personalized therapy with improved efficacy and reduced side effects. The principal approach of cancer vaccines is to induce a specific immune response against cancer cells. However, a major challenge in cancer immunotherapy is to predict which patients will respond to treatment and to monitor the efficacy of the vaccine during treatment. Theragnostics, an integration of diagnostic and therapeutic capabilities into a single hybrid platform system, has the potential to address these challenges by enabling real-time monitoring of treatment response while allowing endogenously controlled personalized treatment adjustments. In this article, we review the current state-of-the-art in theragnostics for cancer vaccines and RNA therapy, including imaging agents, biomarkers, and other diagnostic tools relevant to cancer, and their application in cancer therapy development and personalization. We also discuss the opportunities and challenges for further development and clinical translation of theragnostics in cancer vaccines. |
| format | Article |
| id | doaj-art-e4f11eafe61a449eb19ce577c9fd0f20 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-e4f11eafe61a449eb19ce577c9fd0f202025-01-17T06:51:04ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.14994741499474Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnosticsOlga V. Sergeeva0Liang Luo1Anthony Guiseppi-Elie2Anthony Guiseppi-Elie3Anthony Guiseppi-Elie4Genterra JSC, Moscow, RussiaNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaBioelectronics, Biosensors and Biochips (C3B®), Department of Biomedical Engineering, Texas A&M University, College Station, TX, United StatesDepartment of Cardiovascular Sciences, Houston Methodist Institute for Academic Medicine and Full Affiliate Member, Houston Methodist Research Institute, Houston, TX, United StatesABTECH Scientific, Inc., Biotechnology Research Park, Richmond, VA, United StatesCancer continues to be one of the leading causes of death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, and surgery have limitations. RNA therapy and cancer vaccines hold considerable promise as an alternative to conventional therapies for their ability to enable personalized therapy with improved efficacy and reduced side effects. The principal approach of cancer vaccines is to induce a specific immune response against cancer cells. However, a major challenge in cancer immunotherapy is to predict which patients will respond to treatment and to monitor the efficacy of the vaccine during treatment. Theragnostics, an integration of diagnostic and therapeutic capabilities into a single hybrid platform system, has the potential to address these challenges by enabling real-time monitoring of treatment response while allowing endogenously controlled personalized treatment adjustments. In this article, we review the current state-of-the-art in theragnostics for cancer vaccines and RNA therapy, including imaging agents, biomarkers, and other diagnostic tools relevant to cancer, and their application in cancer therapy development and personalization. We also discuss the opportunities and challenges for further development and clinical translation of theragnostics in cancer vaccines.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1499474/fulltheragnosticscancer vaccineRNA therapybiomarkersimmunotherapypersonalized medicine |
| spellingShingle | Olga V. Sergeeva Liang Luo Anthony Guiseppi-Elie Anthony Guiseppi-Elie Anthony Guiseppi-Elie Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics Frontiers in Bioengineering and Biotechnology theragnostics cancer vaccine RNA therapy biomarkers immunotherapy personalized medicine |
| title | Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics |
| title_full | Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics |
| title_fullStr | Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics |
| title_full_unstemmed | Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics |
| title_short | Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics |
| title_sort | cancer theragnostics closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics |
| topic | theragnostics cancer vaccine RNA therapy biomarkers immunotherapy personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1499474/full |
| work_keys_str_mv | AT olgavsergeeva cancertheragnosticsclosingtheloopforadvancedpersonalizedcancertreatmentthroughtheplatformintegrationoftherapeuticsanddiagnostics AT liangluo cancertheragnosticsclosingtheloopforadvancedpersonalizedcancertreatmentthroughtheplatformintegrationoftherapeuticsanddiagnostics AT anthonyguiseppielie cancertheragnosticsclosingtheloopforadvancedpersonalizedcancertreatmentthroughtheplatformintegrationoftherapeuticsanddiagnostics AT anthonyguiseppielie cancertheragnosticsclosingtheloopforadvancedpersonalizedcancertreatmentthroughtheplatformintegrationoftherapeuticsanddiagnostics AT anthonyguiseppielie cancertheragnosticsclosingtheloopforadvancedpersonalizedcancertreatmentthroughtheplatformintegrationoftherapeuticsanddiagnostics |