Incidence of Congenital Limb Reduction Defects: A Systematic Review
Background: Congenital limb reduction defects (CLRDs) are missing or hypoplastic whole or part of limbs that occur in utero and cause significant functional impairment. This systematic review aims to describe the incidence of CLRDs published to date in the English literature. Methods: A systematic r...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Limb Lengthening & Reconstruction |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jllr.jllr_17_24 |
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| Summary: | Background:
Congenital limb reduction defects (CLRDs) are missing or hypoplastic whole or part of limbs that occur in utero and cause significant functional impairment. This systematic review aims to describe the incidence of CLRDs published to date in the English literature.
Methods:
A systematic review was performed using Ovid Medline, Ovid Embase, Web of Science, and Google Scholar in April 2021. Two independent reviewers performed title and abstract screening, full-text review, and data extraction. Conflicts were resolved by a third independent reviewer. The pooled incidence rate per 10,000 was calculated.
Results:
Search results were performed on April 10, 2021. 2076 articles were screened, 288 studies underwent full-text review, and 100 papers were included for final data analysis. The average pooled incidence of CLRDs was 4.48/10,000 (95% confidence interval = 3.89–5.16) with the highest incidence in Western Asia and the lowest in Eastern Asia. There was a higher incidence of upper limbs, males, and left-sided defects. Incidence has decreased over time (−0.0103, 95% CI = −0.203–−0.003, P = 0.04).
Conclusions:
The incidence of CLRDs published in the English literature to date was calculated, outlining the importance of screening, standardized classification system, and healthcare resource requirements. |
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| ISSN: | 2455-3719 |