Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury
Objective:To observe the effect of enriched environment on neurological function in rats with cerebral ischemia-reperfusion injury.Methods:Sprague-Dawley rats (50-60 g) were randomly assigned to standard environment or enriched environment for 30 days. Each rat's path in the different condition...
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Editorial Office of Rehabilitation Medicine
2017-02-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.01018 |
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| author | Kewei YU Yi WU Hongyu XIE Gang LIU Junfa WU |
| author_facet | Kewei YU Yi WU Hongyu XIE Gang LIU Junfa WU |
| author_sort | Kewei YU |
| collection | DOAJ |
| description | Objective:To observe the effect of enriched environment on neurological function in rats with cerebral ischemia-reperfusion injury.Methods:Sprague-Dawley rats (50-60 g) were randomly assigned to standard environment or enriched environment for 30 days. Each rat's path in the different conditions was recorded using an automated tracking system. And the distance moved (m), velocity (m/s), mobile duration (s) and moving equency were analyzed by Etho Vision XT 7.0 of Noldus information technology company. After 30 days, ischemia was induced by occluding the middle cerebral artery for 90 min, followed by reperfusion, and the successful rats were put back into their environment. After 7 days of the operation, functional outcomes were assessed using neurological deficits scores. CatWalk was used to assess gait changes of rats on day 14 after surgery.Results:The enriched environment rats were significantly more active than the standard environment rats. The neurological deficit score of the standard environment group was significantly higher than that of the enriched environment group (<italic>P</italic><0.05). The functional outcomes of rats in the enriched environment group were better than those in the standard environment group. In the enriched environment group, the gait of rats was significantly better than that of the standard environment group. There were significant statistical differences between the enriched environment group and the standard environment group for the pressure of the foot, the area of foot contact with the contact surface of rats (<italic>P</italic><0.05).Conclusion:Enriched environment can promote the autonomic movement of rats, and the enriched environment can promote the neurological function recovery of rats after cerebral ischemia/reperfusion injury. The CatWalk gait analysis system can sensitively and objectively evaluate the motor function of the rats after cerebral ischemia/reperfusion injury. |
| format | Article |
| id | doaj-art-e4e58c9211d44aefbdbea652f5797708 |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-e4e58c9211d44aefbdbea652f57977082025-01-14T10:05:54ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282017-02-0127182323096986Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion InjuryKewei YUYi WUHongyu XIEGang LIUJunfa WUObjective:To observe the effect of enriched environment on neurological function in rats with cerebral ischemia-reperfusion injury.Methods:Sprague-Dawley rats (50-60 g) were randomly assigned to standard environment or enriched environment for 30 days. Each rat's path in the different conditions was recorded using an automated tracking system. And the distance moved (m), velocity (m/s), mobile duration (s) and moving equency were analyzed by Etho Vision XT 7.0 of Noldus information technology company. After 30 days, ischemia was induced by occluding the middle cerebral artery for 90 min, followed by reperfusion, and the successful rats were put back into their environment. After 7 days of the operation, functional outcomes were assessed using neurological deficits scores. CatWalk was used to assess gait changes of rats on day 14 after surgery.Results:The enriched environment rats were significantly more active than the standard environment rats. The neurological deficit score of the standard environment group was significantly higher than that of the enriched environment group (<italic>P</italic><0.05). The functional outcomes of rats in the enriched environment group were better than those in the standard environment group. In the enriched environment group, the gait of rats was significantly better than that of the standard environment group. There were significant statistical differences between the enriched environment group and the standard environment group for the pressure of the foot, the area of foot contact with the contact surface of rats (<italic>P</italic><0.05).Conclusion:Enriched environment can promote the autonomic movement of rats, and the enriched environment can promote the neurological function recovery of rats after cerebral ischemia/reperfusion injury. The CatWalk gait analysis system can sensitively and objectively evaluate the motor function of the rats after cerebral ischemia/reperfusion injury.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.01018cerebral ischemia-reperfusion injuryenriched environmentgait analysisneurological function |
| spellingShingle | Kewei YU Yi WU Hongyu XIE Gang LIU Junfa WU Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury 康复学报 cerebral ischemia-reperfusion injury enriched environment gait analysis neurological function |
| title | Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury |
| title_full | Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury |
| title_fullStr | Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury |
| title_full_unstemmed | Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury |
| title_short | Experimental Study of Enriched Environment on Neurological Functional Repair in Rats with Cerebral Ischemia-reperfusion Injury |
| title_sort | experimental study of enriched environment on neurological functional repair in rats with cerebral ischemia reperfusion injury |
| topic | cerebral ischemia-reperfusion injury enriched environment gait analysis neurological function |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.01018 |
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