Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice

Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice

The specific role that prolactin plays in lactational infertility, as distinct from other suckling or metabolic cues, remains unresolved. Here, deletion of the prolactin receptor (Prlr) from forebrain neurons or arcuate kisspeptin neurons resulted in failure to maintain normal lactation-induced supp...

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Bibliographic Details
Main Authors: Eleni Hackwell, Sharon R Ladyman, Jenny Clarkson, H James McQullian, Ulrich Boehm, Allan Edward Herbison, Rosemary Brown, David R Grattan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
neuroendocrinology
hypothalamus
kisspeptin
prolactin
lactation
infertility
Online Access:https://elifesciences.org/articles/94570
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