Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives
Abstract Accumulated studies have demonstrated that long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biological processes, such as embryonic development and cell differentiation. Comprehensive transcriptome analysis identifies extensive lncRNAs, gradually elucidating their func...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-03-01
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| Series: | Cell Regeneration |
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| Online Access: | https://doi.org/10.1186/s13619-025-00230-4 |
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| author | Jie Yang Donghui Zhang Wei Jiang |
| author_facet | Jie Yang Donghui Zhang Wei Jiang |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | Abstract Accumulated studies have demonstrated that long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biological processes, such as embryonic development and cell differentiation. Comprehensive transcriptome analysis identifies extensive lncRNAs, gradually elucidating their functions across various contexts. Recent studies have highlighted the essential role of lncRNAs in definitive endoderm differentiation, underscoring their importance in early development. In this review, we have analyzed the features of overlapping, proximal, and desert lncRNAs, classified by genomic location, in pluripotent stem cells (PSCs) and the differentiation derivatives. Furthermore, we focus on the endoderm lineage and review the latest advancements in lncRNA identification and their distinct regulatory mechanisms. By consolidating current knowledge, we aim to provide a clearer perspective on how lncRNAs contribute to endoderm differentiation in different manners. |
| format | Article |
| id | doaj-art-e4beca95effb4d3aaeab0e9d2f07c1e5 |
| institution | OA Journals |
| issn | 2045-9769 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj-art-e4beca95effb4d3aaeab0e9d2f07c1e52025-08-20T02:10:23ZengSpringerOpenCell Regeneration2045-97692025-03-0114111010.1186/s13619-025-00230-4Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectivesJie Yang0Donghui Zhang1Wei Jiang2State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei UniversityState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei UniversityDepartment of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan UniversityAbstract Accumulated studies have demonstrated that long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biological processes, such as embryonic development and cell differentiation. Comprehensive transcriptome analysis identifies extensive lncRNAs, gradually elucidating their functions across various contexts. Recent studies have highlighted the essential role of lncRNAs in definitive endoderm differentiation, underscoring their importance in early development. In this review, we have analyzed the features of overlapping, proximal, and desert lncRNAs, classified by genomic location, in pluripotent stem cells (PSCs) and the differentiation derivatives. Furthermore, we focus on the endoderm lineage and review the latest advancements in lncRNA identification and their distinct regulatory mechanisms. By consolidating current knowledge, we aim to provide a clearer perspective on how lncRNAs contribute to endoderm differentiation in different manners.https://doi.org/10.1186/s13619-025-00230-4LncRNAEndoderm differentiationPluripotent stem cellProximal lncRNADesert lncRNA |
| spellingShingle | Jie Yang Donghui Zhang Wei Jiang Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives Cell Regeneration LncRNA Endoderm differentiation Pluripotent stem cell Proximal lncRNA Desert lncRNA |
| title | Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives |
| title_full | Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives |
| title_fullStr | Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives |
| title_full_unstemmed | Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives |
| title_short | Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives |
| title_sort | long noncoding rna as an emerging regulator of endoderm differentiation progress and perspectives |
| topic | LncRNA Endoderm differentiation Pluripotent stem cell Proximal lncRNA Desert lncRNA |
| url | https://doi.org/10.1186/s13619-025-00230-4 |
| work_keys_str_mv | AT jieyang longnoncodingrnaasanemergingregulatorofendodermdifferentiationprogressandperspectives AT donghuizhang longnoncodingrnaasanemergingregulatorofendodermdifferentiationprogressandperspectives AT weijiang longnoncodingrnaasanemergingregulatorofendodermdifferentiationprogressandperspectives |