Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities
Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. Plant derived compounds hold numerous antimicrobial properties, making them a very capabl...
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Frontiers Media S.A.
2025-01-01
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| author | Zehra Edis Zehra Edis Samir Haj Bloukh Samir Haj Bloukh Akram A. Ashames Akram A. Ashames Moawia M. Al-Tabakha Moawia M. Al-Tabakha Moyad J. S. A. Shahwan Moyad J. S. A. Shahwan Hamed Abu Sara Hamed Abu Sara Sai H. S. Boddu Sai H. S. Boddu Sohaib N. Khan Sohaib N. Khan Ibrahim Haj Bloukh Maram Eladdasy Somayeh Sadeghi Haneen Alkubaisi Iman Haj Bloukh Nageeb A. G. M. Hassan Nageeb A. G. M. Hassan |
| author_facet | Zehra Edis Zehra Edis Samir Haj Bloukh Samir Haj Bloukh Akram A. Ashames Akram A. Ashames Moawia M. Al-Tabakha Moawia M. Al-Tabakha Moyad J. S. A. Shahwan Moyad J. S. A. Shahwan Hamed Abu Sara Hamed Abu Sara Sai H. S. Boddu Sai H. S. Boddu Sohaib N. Khan Sohaib N. Khan Ibrahim Haj Bloukh Maram Eladdasy Somayeh Sadeghi Haneen Alkubaisi Iman Haj Bloukh Nageeb A. G. M. Hassan Nageeb A. G. M. Hassan |
| author_sort | Zehra Edis |
| collection | DOAJ |
| description | Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. Plant derived compounds hold numerous antimicrobial properties, making them a very capable source to counteract resistant microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies to contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, and insecticidal properties. It has also been used historically for its pain relief especially for tooth ache. Clove extract derived nanoparticle synthesis is a promising method of combining therapeutics with metals at nanoscale. Such nanostructured systems in combination with the heterocyclic antibiotic clarithromycin could potentiate the action of plant extracts, decrease drug side effects and improve antimicrobial activity. In this study, clove extract (C) was successfully used to synthesize silver nanoparticles (AgNP) to create AgNPC and AgNPCA (A = clarithromycin). The two compounds underwent different analytical methods consisting of SEM, EDS, DLS, UV-vis, FTIR and XRD. These nanoparticles were used against a variety of 10 pathogens and exhibited very good to intermediate antibacterial properties. AgNPC resulted in better antibacterial properties and smaller nanoparticle size. This study demonstrates the potential of clove extract mediated AgNP synthesis in combination with and without the antibiotic clarithromycin. |
| format | Article |
| id | doaj-art-e4bca00140f54f8cbcf69f3b171b0ecc |
| institution | Kabale University |
| issn | 2296-2646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj-art-e4bca00140f54f8cbcf69f3b171b0ecc2025-01-15T06:10:50ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462025-01-011210.3389/fchem.2024.15131501513150Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activitiesZehra Edis0Zehra Edis1Samir Haj Bloukh2Samir Haj Bloukh3Akram A. Ashames4Akram A. Ashames5Moawia M. Al-Tabakha6Moawia M. Al-Tabakha7Moyad J. S. A. Shahwan8Moyad J. S. A. Shahwan9Hamed Abu Sara10Hamed Abu Sara11Sai H. S. Boddu12Sai H. S. Boddu13Sohaib N. Khan14Sohaib N. Khan15Ibrahim Haj Bloukh16Maram Eladdasy17Somayeh Sadeghi18Haneen Alkubaisi19Iman Haj Bloukh20Nageeb A. G. M. Hassan21Nageeb A. G. M. Hassan22Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesCollege of Dentistry, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesCollege of Dentistry, Ajman University, Ajman, United Arab EmiratesCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesDepartment of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab EmiratesMicroorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. Plant derived compounds hold numerous antimicrobial properties, making them a very capable source to counteract resistant microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies to contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, and insecticidal properties. It has also been used historically for its pain relief especially for tooth ache. Clove extract derived nanoparticle synthesis is a promising method of combining therapeutics with metals at nanoscale. Such nanostructured systems in combination with the heterocyclic antibiotic clarithromycin could potentiate the action of plant extracts, decrease drug side effects and improve antimicrobial activity. In this study, clove extract (C) was successfully used to synthesize silver nanoparticles (AgNP) to create AgNPC and AgNPCA (A = clarithromycin). The two compounds underwent different analytical methods consisting of SEM, EDS, DLS, UV-vis, FTIR and XRD. These nanoparticles were used against a variety of 10 pathogens and exhibited very good to intermediate antibacterial properties. AgNPC resulted in better antibacterial properties and smaller nanoparticle size. This study demonstrates the potential of clove extract mediated AgNP synthesis in combination with and without the antibiotic clarithromycin.https://www.frontiersin.org/articles/10.3389/fchem.2024.1513150/fullsilver nanoparticlesantibiotic resistanceclarithromycinheterocyclic antibioticplant extractclove |
| spellingShingle | Zehra Edis Zehra Edis Samir Haj Bloukh Samir Haj Bloukh Akram A. Ashames Akram A. Ashames Moawia M. Al-Tabakha Moawia M. Al-Tabakha Moyad J. S. A. Shahwan Moyad J. S. A. Shahwan Hamed Abu Sara Hamed Abu Sara Sai H. S. Boddu Sai H. S. Boddu Sohaib N. Khan Sohaib N. Khan Ibrahim Haj Bloukh Maram Eladdasy Somayeh Sadeghi Haneen Alkubaisi Iman Haj Bloukh Nageeb A. G. M. Hassan Nageeb A. G. M. Hassan Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities Frontiers in Chemistry silver nanoparticles antibiotic resistance clarithromycin heterocyclic antibiotic plant extract clove |
| title | Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities |
| title_full | Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities |
| title_fullStr | Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities |
| title_full_unstemmed | Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities |
| title_short | Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities |
| title_sort | syzygium aromaticum extract mediated sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities |
| topic | silver nanoparticles antibiotic resistance clarithromycin heterocyclic antibiotic plant extract clove |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1513150/full |
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