Long-term observation of the in vivo safety of a new design of phakic refractive lens
Abstract Background To evaluate the biosafety, reduction in anterior capsule opacification, and fluctuation in intraocular pressure (IOP) of a new phakic refractive lens (PRL) with a sinusoidal drainage groove design. Methods This self-controlled experiment was performed on eight eyes of four rabbit...
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BMC
2025-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03803-0 |
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| author | Yinjie Jiang Xun Chen Mingrui Cheng I-Chun Lin Boliang Li Xinjie Zhu Guanghan Xu Huamao Miao Xiaoying Wang Xingtao Zhou |
| author_facet | Yinjie Jiang Xun Chen Mingrui Cheng I-Chun Lin Boliang Li Xinjie Zhu Guanghan Xu Huamao Miao Xiaoying Wang Xingtao Zhou |
| author_sort | Yinjie Jiang |
| collection | DOAJ |
| description | Abstract Background To evaluate the biosafety, reduction in anterior capsule opacification, and fluctuation in intraocular pressure (IOP) of a new phakic refractive lens (PRL) with a sinusoidal drainage groove design. Methods This self-controlled experiment was performed on eight eyes of four rabbits. Each rabbit was implanted with a sinusoidal PRL (PRL-S5) in the right eye and a conventional posterior chamber PRL (PC-PRL) in the left eye. Slit-lamp examinations, optical coherence tomography, and IOP evaluation were performed before surgery and at 1 day, 1 week, 3 months, 6 months, and 1 year postoperatively in each eye. Gross examination, histopathology, and electron microscopy of the capsule and PRL were performed 1 year postoperatively. Results On slit-lamp examination, the inflammatory reactions recovered one week after surgery. The PC-PRL group developed anterior subcapsular cataracts at 3 months postoperatively and diffuse and dense opacification of the cortex at 1 year. PRL-S5 showed mild local opacification in the optical zone 6 months postoperatively, which did not progress significantly. At 1 year, PC-PRLs had greater opacification (27.37–72.17%) than PRL S5 (6.63–66.96%). Three months after surgery, one eye in the PC-PRL group had scleral staphyloma, one eye had corneal edema, and one eye experienced nasal hepatic prolapse into the anterior chamber. One eye in the PRL-S5 group had papillary membranes but recovered 6 months postoperatively. Histopathological examination revealed liquefaction and necrosis of the opacified area in the center of the subcapsular membrane in both groups. Numerous granular bodies and fibrous precipitates were observed in epithelial cells in the opaque area. Electron microscopy showed that epithelial cells proliferated on the surface of all anterior capsule membranes, with no significant differences between the two groups. The capsular PC-PRL group showed anterior cortical proliferation and fibrosis. An IOP elevation was noted on the first postoperative day (18.8 to 37.9 mmHg). However, both the PC-PRL and PRL-S5 groups exhibited relatively stable IOP levels 1 week, 3 months, 6 months, and 1 year postoperatively. Conclusions The new PRL exhibited robust long-term biocompatibility. The sinusoidal groove design facilitated the maintenance of IOP stability without necessitating iridectomy and effectively mitigated the onset and progression of cataracts. |
| format | Article |
| id | doaj-art-e4b16f8fed2f4ec78b3b43c8f98379b4 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-e4b16f8fed2f4ec78b3b43c8f98379b42025-01-12T12:12:23ZengBMCBMC Ophthalmology1471-24152025-01-0125111110.1186/s12886-024-03803-0Long-term observation of the in vivo safety of a new design of phakic refractive lensYinjie Jiang0Xun Chen1Mingrui Cheng2I-Chun Lin3Boliang Li4Xinjie Zhu5Guanghan Xu6Huamao Miao7Xiaoying Wang8Xingtao Zhou9Fudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalFudan University Eye Ear Nose and Throat HospitalAbstract Background To evaluate the biosafety, reduction in anterior capsule opacification, and fluctuation in intraocular pressure (IOP) of a new phakic refractive lens (PRL) with a sinusoidal drainage groove design. Methods This self-controlled experiment was performed on eight eyes of four rabbits. Each rabbit was implanted with a sinusoidal PRL (PRL-S5) in the right eye and a conventional posterior chamber PRL (PC-PRL) in the left eye. Slit-lamp examinations, optical coherence tomography, and IOP evaluation were performed before surgery and at 1 day, 1 week, 3 months, 6 months, and 1 year postoperatively in each eye. Gross examination, histopathology, and electron microscopy of the capsule and PRL were performed 1 year postoperatively. Results On slit-lamp examination, the inflammatory reactions recovered one week after surgery. The PC-PRL group developed anterior subcapsular cataracts at 3 months postoperatively and diffuse and dense opacification of the cortex at 1 year. PRL-S5 showed mild local opacification in the optical zone 6 months postoperatively, which did not progress significantly. At 1 year, PC-PRLs had greater opacification (27.37–72.17%) than PRL S5 (6.63–66.96%). Three months after surgery, one eye in the PC-PRL group had scleral staphyloma, one eye had corneal edema, and one eye experienced nasal hepatic prolapse into the anterior chamber. One eye in the PRL-S5 group had papillary membranes but recovered 6 months postoperatively. Histopathological examination revealed liquefaction and necrosis of the opacified area in the center of the subcapsular membrane in both groups. Numerous granular bodies and fibrous precipitates were observed in epithelial cells in the opaque area. Electron microscopy showed that epithelial cells proliferated on the surface of all anterior capsule membranes, with no significant differences between the two groups. The capsular PC-PRL group showed anterior cortical proliferation and fibrosis. An IOP elevation was noted on the first postoperative day (18.8 to 37.9 mmHg). However, both the PC-PRL and PRL-S5 groups exhibited relatively stable IOP levels 1 week, 3 months, 6 months, and 1 year postoperatively. Conclusions The new PRL exhibited robust long-term biocompatibility. The sinusoidal groove design facilitated the maintenance of IOP stability without necessitating iridectomy and effectively mitigated the onset and progression of cataracts.https://doi.org/10.1186/s12886-024-03803-0Refractive surgeryPhakic Intraocular LensPhakic Refractive LensComplicationsIntraocular pressureCataract |
| spellingShingle | Yinjie Jiang Xun Chen Mingrui Cheng I-Chun Lin Boliang Li Xinjie Zhu Guanghan Xu Huamao Miao Xiaoying Wang Xingtao Zhou Long-term observation of the in vivo safety of a new design of phakic refractive lens BMC Ophthalmology Refractive surgery Phakic Intraocular Lens Phakic Refractive Lens Complications Intraocular pressure Cataract |
| title | Long-term observation of the in vivo safety of a new design of phakic refractive lens |
| title_full | Long-term observation of the in vivo safety of a new design of phakic refractive lens |
| title_fullStr | Long-term observation of the in vivo safety of a new design of phakic refractive lens |
| title_full_unstemmed | Long-term observation of the in vivo safety of a new design of phakic refractive lens |
| title_short | Long-term observation of the in vivo safety of a new design of phakic refractive lens |
| title_sort | long term observation of the in vivo safety of a new design of phakic refractive lens |
| topic | Refractive surgery Phakic Intraocular Lens Phakic Refractive Lens Complications Intraocular pressure Cataract |
| url | https://doi.org/10.1186/s12886-024-03803-0 |
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