Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
Abstract Purpose: This study aimed to evaluate responses in retinal tissue by swept source OCT angiography (OCT-A) to hyperoxia after hyperbaric oxygen (HBO2) therapy. Methods: The study was conducted in volunteers who received HBO2 treatment but did not have any eye disease. Patients underwent deta...
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Knowledge E
2021-07-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://doi.org/10.18502/jovr.v16i3.9436 |
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| author | Sadık Görkem Çevik Bekir Selim Bağlı |
| author_facet | Sadık Görkem Çevik Bekir Selim Bağlı |
| author_sort | Sadık Görkem Çevik |
| collection | DOAJ |
| description | Abstract Purpose: This study aimed to evaluate responses in retinal tissue by swept source OCT angiography (OCT-A) to hyperoxia after hyperbaric oxygen (HBO2) therapy. Methods: The study was conducted in volunteers who received HBO2 treatment but did not have any eye disease. Patients underwent detailed eye examinations including dilated fundus examination, visual acuity, and refraction before being admitted for HBO2 therapy. Measurements were made before and immediately after HBO2 therapy. Enface images of the retinal vasculature were obtained from the superficial and deep retinal plexus (SP/DP). Quantitative analysis of the vessel density (VD) and foveal avascular zone (FAZ) area was performed. Results: In total, 31 patients (15 female) with healthy retina were included in the study. The mean age was 42.8 years. The mean SP vascular density measurements before HBO2 therapy for the right and left eyes were 15.18 ± 1.2 mm - 1 and 15.01 ± 1.3 mm - 1 , respectively; the measurements after HBO2 therapy for the right and left eyes were 14.34 ± 1.4 mm - 1 and 14.48 ± 1.19 mm - 1 . The mean DP vascular density measurements before HBO2 therapy for the right and left eyes were 16.03 ± 1.69 mm - 1 and 16.1 ± 1.45 mm - 1 , respectively; the measurements after HBO2 therapy for the right and left eyes were 15.02 ± 1.65 mm - 1 and 15.12 ± 2.16 mm - 1 , respectively. Reduction of mean VD in superficial and deep plexus after HBO2 was statistically significant (P = 0.001 and P = 0.000, respectively). Changes in mean FAZ area before and after HBO2 therapy were not statistically significant (P = 0.719). Conclusion: The healthy retina responds to oxygen supersaturation with HBO2 therapy by eventually decreasing vascular density in all layers. These findings may be important for further studies especially related to retina and choroidal oxygenation. |
| format | Article |
| id | doaj-art-e48e133373dc40e0ba31e17f8ec71c0e |
| institution | Kabale University |
| issn | 2008-2010 2008-322X |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj-art-e48e133373dc40e0ba31e17f8ec71c0e2025-01-13T10:02:33ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2021-07-0116339339910.18502/jovr.v16i3.9436jovr.v16i3.9436Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy RetinaSadık Görkem Çevik0Bekir Selim Bağlı1 Department of Ophthalmology, Yuksek Ihtisas Education and Training Hospital, Bursa, Turkey Department of Underwater and Hyperbaric Medicine, Yuksek Ihtisas Education and Training Hospital, Bursa, TurkeyAbstract Purpose: This study aimed to evaluate responses in retinal tissue by swept source OCT angiography (OCT-A) to hyperoxia after hyperbaric oxygen (HBO2) therapy. Methods: The study was conducted in volunteers who received HBO2 treatment but did not have any eye disease. Patients underwent detailed eye examinations including dilated fundus examination, visual acuity, and refraction before being admitted for HBO2 therapy. Measurements were made before and immediately after HBO2 therapy. Enface images of the retinal vasculature were obtained from the superficial and deep retinal plexus (SP/DP). Quantitative analysis of the vessel density (VD) and foveal avascular zone (FAZ) area was performed. Results: In total, 31 patients (15 female) with healthy retina were included in the study. The mean age was 42.8 years. The mean SP vascular density measurements before HBO2 therapy for the right and left eyes were 15.18 ± 1.2 mm - 1 and 15.01 ± 1.3 mm - 1 , respectively; the measurements after HBO2 therapy for the right and left eyes were 14.34 ± 1.4 mm - 1 and 14.48 ± 1.19 mm - 1 . The mean DP vascular density measurements before HBO2 therapy for the right and left eyes were 16.03 ± 1.69 mm - 1 and 16.1 ± 1.45 mm - 1 , respectively; the measurements after HBO2 therapy for the right and left eyes were 15.02 ± 1.65 mm - 1 and 15.12 ± 2.16 mm - 1 , respectively. Reduction of mean VD in superficial and deep plexus after HBO2 was statistically significant (P = 0.001 and P = 0.000, respectively). Changes in mean FAZ area before and after HBO2 therapy were not statistically significant (P = 0.719). Conclusion: The healthy retina responds to oxygen supersaturation with HBO2 therapy by eventually decreasing vascular density in all layers. These findings may be important for further studies especially related to retina and choroidal oxygenation.https://doi.org/10.18502/jovr.v16i3.9436hyperbaric oxygenoct-aretinal ischemic disease |
| spellingShingle | Sadık Görkem Çevik Bekir Selim Bağlı Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina Journal of Ophthalmic & Vision Research hyperbaric oxygen oct-a retinal ischemic disease |
| title | Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina |
| title_full | Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina |
| title_fullStr | Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina |
| title_full_unstemmed | Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina |
| title_short | Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina |
| title_sort | change in the foveal avascular zone and macular capillary network density after hyperbaric oxygen therapy in healthy retina |
| topic | hyperbaric oxygen oct-a retinal ischemic disease |
| url | https://doi.org/10.18502/jovr.v16i3.9436 |
| work_keys_str_mv | AT sadıkgorkemcevik changeinthefovealavascularzoneandmacularcapillarynetworkdensityafterhyperbaricoxygentherapyinhealthyretina AT bekirselimbaglı changeinthefovealavascularzoneandmacularcapillarynetworkdensityafterhyperbaricoxygentherapyinhealthyretina |