Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis
Abstract Background Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian rando...
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2025-01-01
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| author | Li-Hui Fang Jia-Qi Zhang Jin-Ke Huang Xu-Dong Tang |
| author_facet | Li-Hui Fang Jia-Qi Zhang Jin-Ke Huang Xu-Dong Tang |
| author_sort | Li-Hui Fang |
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| description | Abstract Background Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method. Methods We obtained data from genome-wide association studies (GWASs) in European individuals for IBD and its main subtypes, Crohn’s disease (CD) and ulcerative colitis (UC) (31,665 IBD cases, 13,768 UC cases, 17,897 CD cases and 33,977 controls). Four independent summary statistics of pancreatitis from the the European Bioinformatics Institute (EMBL-EBI, 10,630 AP cases and 844,679 controls, 1,424 CP cases and 476,104 controls) and FinnGen Consortium (8,446 AP cases, 4,820 CP cases and 437,418 controls) were used for bidirectional MR analyses and sensitivity analysis. Finally, further meta-analysis was conducted on the MR results. Results Generally, IBD is associated with an increased risk of pancreatitis (IBD-AP, OR = 1.050, 95% CI 1.020–1.080, P = 7.20 × 10–5; IBD-CP, OR = 1.050, 95% CI 1.010–1.090, P = 0.019). In addition, UC increased the risk of pancreatitis (UC-AP, OR = 1.050, 95% CI 1.020–1.070, P = 9.10 × 10–5; UC-CP, OR = 1.090, 95% CI 1.040–1.140, P = 1.44 × 10–4) and CD increased the risk of acute pancreatitis (OR = 1.040, 95% CI 1.020–1.060, P = 9.61 × 10–5). However, no causal association was found between CD and the risk of chronic pancreatitis (P > 0.05). The reverse MR results showed that AP may be associated with a reduced risk of IBD and CD (AP-IBD, OR = 0.880, 95% CI 0.810–0.960, P = 0.003; AP-CD, OR = 0.830, 95% CI 0.730–0.940, P = 0.003). However, there is no causal relationship between AP and the risk of UC, and there is no causal relationship between CP and the risk of IBD and its subtypes(P > 0.05). Conclusion In conclusion, based on MR analysis and meta-analysis, our results showed a positive causal effect of IBD on pancreatitis, and subgroup analyses showed that UC and CD may promote the development of acute pancreatitis, whereas UC may promote the development of chronic pancreatitis. Reverse MR analysis suggests that AP may have a potential protective effect on IBD and CD. |
| format | Article |
| id | doaj-art-e47d2d1eeab44e8aaded64613a57dfd9 |
| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-e47d2d1eeab44e8aaded64613a57dfd92025-01-12T12:26:11ZengBMCBMC Gastroenterology1471-230X2025-01-0125111110.1186/s12876-024-03571-7Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysisLi-Hui Fang0Jia-Qi Zhang1Jin-Ke Huang2Xu-Dong Tang3Graduate School, Beijing University of Chinese MedicineInstitute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical SciencesInstitute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical SciencesInstitute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical SciencesAbstract Background Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method. Methods We obtained data from genome-wide association studies (GWASs) in European individuals for IBD and its main subtypes, Crohn’s disease (CD) and ulcerative colitis (UC) (31,665 IBD cases, 13,768 UC cases, 17,897 CD cases and 33,977 controls). Four independent summary statistics of pancreatitis from the the European Bioinformatics Institute (EMBL-EBI, 10,630 AP cases and 844,679 controls, 1,424 CP cases and 476,104 controls) and FinnGen Consortium (8,446 AP cases, 4,820 CP cases and 437,418 controls) were used for bidirectional MR analyses and sensitivity analysis. Finally, further meta-analysis was conducted on the MR results. Results Generally, IBD is associated with an increased risk of pancreatitis (IBD-AP, OR = 1.050, 95% CI 1.020–1.080, P = 7.20 × 10–5; IBD-CP, OR = 1.050, 95% CI 1.010–1.090, P = 0.019). In addition, UC increased the risk of pancreatitis (UC-AP, OR = 1.050, 95% CI 1.020–1.070, P = 9.10 × 10–5; UC-CP, OR = 1.090, 95% CI 1.040–1.140, P = 1.44 × 10–4) and CD increased the risk of acute pancreatitis (OR = 1.040, 95% CI 1.020–1.060, P = 9.61 × 10–5). However, no causal association was found between CD and the risk of chronic pancreatitis (P > 0.05). The reverse MR results showed that AP may be associated with a reduced risk of IBD and CD (AP-IBD, OR = 0.880, 95% CI 0.810–0.960, P = 0.003; AP-CD, OR = 0.830, 95% CI 0.730–0.940, P = 0.003). However, there is no causal relationship between AP and the risk of UC, and there is no causal relationship between CP and the risk of IBD and its subtypes(P > 0.05). Conclusion In conclusion, based on MR analysis and meta-analysis, our results showed a positive causal effect of IBD on pancreatitis, and subgroup analyses showed that UC and CD may promote the development of acute pancreatitis, whereas UC may promote the development of chronic pancreatitis. Reverse MR analysis suggests that AP may have a potential protective effect on IBD and CD.https://doi.org/10.1186/s12876-024-03571-7Inflammatory bowel diseaseAcute pancreatitisChronic pancreatitisMendelian randomizationUlcerative colitisCrohn's disease |
| spellingShingle | Li-Hui Fang Jia-Qi Zhang Jin-Ke Huang Xu-Dong Tang Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis BMC Gastroenterology Inflammatory bowel disease Acute pancreatitis Chronic pancreatitis Mendelian randomization Ulcerative colitis Crohn's disease |
| title | Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis |
| title_full | Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis |
| title_fullStr | Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis |
| title_full_unstemmed | Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis |
| title_short | Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis |
| title_sort | inflammatory bowel disease increases the risk of pancreatitis a two sample bidirectional mendelian randomization analysis |
| topic | Inflammatory bowel disease Acute pancreatitis Chronic pancreatitis Mendelian randomization Ulcerative colitis Crohn's disease |
| url | https://doi.org/10.1186/s12876-024-03571-7 |
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