Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence?
Introduction: It has been suggested that patients with autoimmune diseases are more likely to develop other malignancies. However, the association between lupus and multiple myeloma (MM) is still not much described in the literature. Case Report: We report the observation of a 46-year-old female...
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Knowledge E
2024-12-01
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| Series: | Dubai Medical Journal |
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| author | Sara Anibar Ihsene Cherradi Mohammed Bouchoual Marouane Jabrane Mohamed Arrayhani |
| author_facet | Sara Anibar Ihsene Cherradi Mohammed Bouchoual Marouane Jabrane Mohamed Arrayhani |
| author_sort | Sara Anibar |
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Introduction: It has been suggested that patients with autoimmune diseases are more likely to develop other malignancies. However, the association between lupus and multiple myeloma (MM) is still not much described in the literature.
Case Report: We report the observation of a 46-year-old female patient, in premenopause, in whom the diagnosis of systemic lupus was retained (SLICC criteria 7) with cutaneous, joint, hematological, immunological, and renal involvement. The discovery of MM was suspected due to a peak in gamma globulins on plasma protein electrophoresis and confirmed by myelogram. The outcome was fatal due to septic shock before starting any immunosuppression.
Discussion and Conclusion: In this literature review, 15 cases are reported on the occurrence of MM years after the diagnosis of lupus, only two cases were like our observation with a concomitant diagnosis of the 2 diseases. The management is still not codified; hence the prognosis of this association remains reserved, encouraging early detection of malignant plasma cell proliferation.
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| format | Article |
| id | doaj-art-e4778b7de629486f8be31db7bb86664d |
| institution | Kabale University |
| issn | 2571-726X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Dubai Medical Journal |
| spelling | doaj-art-e4778b7de629486f8be31db7bb86664d2025-01-02T14:31:38ZengKnowledge EDubai Medical Journal2571-726X2024-12-017410.18502/dmj.v7i4.17807Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence?Sara Anibar0Ihsene Cherradi1Mohammed Bouchoual2Marouane Jabrane3Mohamed Arrayhani4Nephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, AgadirNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, AgadirNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, AgadirNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, AgadirNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, Agadir Introduction: It has been suggested that patients with autoimmune diseases are more likely to develop other malignancies. However, the association between lupus and multiple myeloma (MM) is still not much described in the literature. Case Report: We report the observation of a 46-year-old female patient, in premenopause, in whom the diagnosis of systemic lupus was retained (SLICC criteria 7) with cutaneous, joint, hematological, immunological, and renal involvement. The discovery of MM was suspected due to a peak in gamma globulins on plasma protein electrophoresis and confirmed by myelogram. The outcome was fatal due to septic shock before starting any immunosuppression. Discussion and Conclusion: In this literature review, 15 cases are reported on the occurrence of MM years after the diagnosis of lupus, only two cases were like our observation with a concomitant diagnosis of the 2 diseases. The management is still not codified; hence the prognosis of this association remains reserved, encouraging early detection of malignant plasma cell proliferation. https://www.knepublishing.com/index.php/DMJ/article/view/17807multiple myelomasystemic lupusconcomitantdiagnostic |
| spellingShingle | Sara Anibar Ihsene Cherradi Mohammed Bouchoual Marouane Jabrane Mohamed Arrayhani Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence? Dubai Medical Journal multiple myeloma systemic lupus concomitant diagnostic |
| title | Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence? |
| title_full | Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence? |
| title_fullStr | Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence? |
| title_full_unstemmed | Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence? |
| title_short | Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence? |
| title_sort | concomitant discovery of systemic lupus and multiple myeloma is it a coincidence |
| topic | multiple myeloma systemic lupus concomitant diagnostic |
| url | https://www.knepublishing.com/index.php/DMJ/article/view/17807 |
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