The role of the extracellular matrix in cardiac regeneration
The extracellular matrix (ECM) is a complex and dynamic three-dimensional network that functions as an architectural scaffold to maintain cardiac homeostasis. Important biochemical and mechanical signals associated with cell‒cell communication are provided via the reciprocal interaction between cell...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024171885 |
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| author | Xiying Wang Shuo Yu Lan Xie Meixiang Xiang Hong Ma |
| author_facet | Xiying Wang Shuo Yu Lan Xie Meixiang Xiang Hong Ma |
| author_sort | Xiying Wang |
| collection | DOAJ |
| description | The extracellular matrix (ECM) is a complex and dynamic three-dimensional network that functions as an architectural scaffold to maintain cardiac homeostasis. Important biochemical and mechanical signals associated with cell‒cell communication are provided via the reciprocal interaction between cells and the ECM. By converting mechanical cues into biochemical signals, the ECM regulates many cell processes, including migration, adhesion, growth, differentiation, proliferation, and apoptosis. Moreover, the ECM facilitates the replacement of dead cells and preserves the structural integrity of the heart, making it essential in conditions such as myocardial infarction and other pathological states. When excessive ECM deposition or abnormal production of ECM components occurs, the heart undergoes fibrosis, leading to cardiac dysfunction and heart failure. However, emerging evidence suggests that the ECM may contribute to heart regeneration following cardiac injury. The present review offers a complete overview of the existing information and novel discoveries regarding the involvement of the ECM in heart regeneration from both mechanical and biochemical perspectives. Understanding the ECM and its involvement in mechanotransduction holds significant potential for advancing therapeutic approaches in heart repair and regeneration. |
| format | Article |
| id | doaj-art-e45bb8a1098645d3a6a4d5d019a14adc |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e45bb8a1098645d3a6a4d5d019a14adc2025-01-17T04:50:20ZengElsevierHeliyon2405-84402025-01-01111e41157The role of the extracellular matrix in cardiac regenerationXiying Wang0Shuo Yu1Lan Xie2Meixiang Xiang3Hong Ma4Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Department of Rheumatology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, ChinaDepartment of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China; Corresponding author. Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China; Corresponding author. Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.The extracellular matrix (ECM) is a complex and dynamic three-dimensional network that functions as an architectural scaffold to maintain cardiac homeostasis. Important biochemical and mechanical signals associated with cell‒cell communication are provided via the reciprocal interaction between cells and the ECM. By converting mechanical cues into biochemical signals, the ECM regulates many cell processes, including migration, adhesion, growth, differentiation, proliferation, and apoptosis. Moreover, the ECM facilitates the replacement of dead cells and preserves the structural integrity of the heart, making it essential in conditions such as myocardial infarction and other pathological states. When excessive ECM deposition or abnormal production of ECM components occurs, the heart undergoes fibrosis, leading to cardiac dysfunction and heart failure. However, emerging evidence suggests that the ECM may contribute to heart regeneration following cardiac injury. The present review offers a complete overview of the existing information and novel discoveries regarding the involvement of the ECM in heart regeneration from both mechanical and biochemical perspectives. Understanding the ECM and its involvement in mechanotransduction holds significant potential for advancing therapeutic approaches in heart repair and regeneration.http://www.sciencedirect.com/science/article/pii/S2405844024171885Extracellular matrixFibroblastsHeart failureHeart regenerationMechanics |
| spellingShingle | Xiying Wang Shuo Yu Lan Xie Meixiang Xiang Hong Ma The role of the extracellular matrix in cardiac regeneration Heliyon Extracellular matrix Fibroblasts Heart failure Heart regeneration Mechanics |
| title | The role of the extracellular matrix in cardiac regeneration |
| title_full | The role of the extracellular matrix in cardiac regeneration |
| title_fullStr | The role of the extracellular matrix in cardiac regeneration |
| title_full_unstemmed | The role of the extracellular matrix in cardiac regeneration |
| title_short | The role of the extracellular matrix in cardiac regeneration |
| title_sort | role of the extracellular matrix in cardiac regeneration |
| topic | Extracellular matrix Fibroblasts Heart failure Heart regeneration Mechanics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024171885 |
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