Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1

Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1

Abstract Background Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved. Methods First, a fibrotic model of FAPs was induced, and FAPs were cultu...

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Bibliographic Details
Main Authors: Yuesong Yin, Hai Hu, Yian Yang, Song Wu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Ginsenoside Rb1
SFRP1
Wnt
Ca2+
Rotator cuff tears
Online Access:https://doi.org/10.1186/s10020-024-01009-0
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https://doi.org/10.1186/s10020-024-01009-0

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