Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination.
<h4>Background</h4>COVID-19 infection and vaccination have been reported to confer an elevated risk for cardiovascular events (CVE). We sought to determine whether individuals with an underlying vascular connective tissue disorder including Marfan syndrome (MFS), Loeys-Dietz syndrome (LD...
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| Format: | Article |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315499 |
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| author | Anthony L Guerrerio Allyson Mateja Gretchen MacCarrick Jonathan Fintzi Erica Brittain Pamela A Frischmeyer-Guerrerio Harry C Dietz |
| author_facet | Anthony L Guerrerio Allyson Mateja Gretchen MacCarrick Jonathan Fintzi Erica Brittain Pamela A Frischmeyer-Guerrerio Harry C Dietz |
| author_sort | Anthony L Guerrerio |
| collection | DOAJ |
| description | <h4>Background</h4>COVID-19 infection and vaccination have been reported to confer an elevated risk for cardiovascular events (CVE). We sought to determine whether individuals with an underlying vascular connective tissue disorder including Marfan syndrome (MFS), Loeys-Dietz syndrome (LDS), or vascular Ehlers Danlos syndrome (vEDS) are at increased risk for cardiac events after COVID-19 infection or vaccination.<h4>Methods</h4>325 respondents self-reported data through a cross-sectional, web-based survey available from 22 November 2021, through 15 March 2022 regarding COVID-19 illness and vaccinations, the occurrence of any CVE, and adverse events following vaccination. The data were analyzed using a Cox proportional hazards model with time varying indicators for COVID-19 illness/vaccination in the preceding 30 days.<h4>Results</h4>COVID-19 illness was significantly associated with an increased rate of a new abnormal heart rhythm 30 days following infection. No other CVEs were reported in the 90 days after COVID-19 illness. We did not find evidence of an increased rate of any CVE in the 30 days following any COVID-19 vaccination dose.<h4>Conclusion</h4>In respondents with MFS, LDS, or vEDS, we uncovered no evidence of an increase in CVEs in the 30 days following COVID-19 illness, with the possible exception of dysrhythmia. In light of the absence of a substantial increase in self-reported CVEs in the 30 days following COVID-19 vaccination, these data are in keeping with the recommendation from the Marfan Foundation Professional Advisory Board that all eligible persons be vaccinated for COVID-19. |
| format | Article |
| id | doaj-art-e4269b8d0db24b6c888b0aee5afaa4e4 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e4269b8d0db24b6c888b0aee5afaa4e42025-01-08T05:32:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031549910.1371/journal.pone.0315499Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination.Anthony L GuerrerioAllyson MatejaGretchen MacCarrickJonathan FintziErica BrittainPamela A Frischmeyer-GuerrerioHarry C Dietz<h4>Background</h4>COVID-19 infection and vaccination have been reported to confer an elevated risk for cardiovascular events (CVE). We sought to determine whether individuals with an underlying vascular connective tissue disorder including Marfan syndrome (MFS), Loeys-Dietz syndrome (LDS), or vascular Ehlers Danlos syndrome (vEDS) are at increased risk for cardiac events after COVID-19 infection or vaccination.<h4>Methods</h4>325 respondents self-reported data through a cross-sectional, web-based survey available from 22 November 2021, through 15 March 2022 regarding COVID-19 illness and vaccinations, the occurrence of any CVE, and adverse events following vaccination. The data were analyzed using a Cox proportional hazards model with time varying indicators for COVID-19 illness/vaccination in the preceding 30 days.<h4>Results</h4>COVID-19 illness was significantly associated with an increased rate of a new abnormal heart rhythm 30 days following infection. No other CVEs were reported in the 90 days after COVID-19 illness. We did not find evidence of an increased rate of any CVE in the 30 days following any COVID-19 vaccination dose.<h4>Conclusion</h4>In respondents with MFS, LDS, or vEDS, we uncovered no evidence of an increase in CVEs in the 30 days following COVID-19 illness, with the possible exception of dysrhythmia. In light of the absence of a substantial increase in self-reported CVEs in the 30 days following COVID-19 vaccination, these data are in keeping with the recommendation from the Marfan Foundation Professional Advisory Board that all eligible persons be vaccinated for COVID-19.https://doi.org/10.1371/journal.pone.0315499 |
| spellingShingle | Anthony L Guerrerio Allyson Mateja Gretchen MacCarrick Jonathan Fintzi Erica Brittain Pamela A Frischmeyer-Guerrerio Harry C Dietz Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. PLoS ONE |
| title | Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. |
| title_full | Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. |
| title_fullStr | Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. |
| title_full_unstemmed | Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. |
| title_short | Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination. |
| title_sort | cardiovascular complications in vascular connective tissue disorders after covid 19 infection and vaccination |
| url | https://doi.org/10.1371/journal.pone.0315499 |
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