The role of SRP9/SRP14 in regulating Alu RNA
SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL is mediated through a conserved structural motif that is shared with the primate-specific Al...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2430817 |
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| author | Daniel Gussakovsky Nicole A. Black Evan P. Booy Sean A. McKenna |
| author_facet | Daniel Gussakovsky Nicole A. Black Evan P. Booy Sean A. McKenna |
| author_sort | Daniel Gussakovsky |
| collection | DOAJ |
| description | SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL is mediated through a conserved structural motif that is shared with the primate-specific Alu RNA. Alu RNA are transcription products of Alu elements, a retroelement that comprises ~10% of the human genome. Alu RNA are involved in myriad biological processes and are dysregulated in several human disease states. This review focuses on the roles SRP9/SRP14 has in regulating Alu RNA diversification, maturation, and function. The diverse mechanisms through which SRP9/SRP14 regulates Alu RNA exemplify the breadth of protein-mediated regulation of non-coding RNA. |
| format | Article |
| id | doaj-art-e4105cb29a964b48a63e898abbdf19f6 |
| institution | Kabale University |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-e4105cb29a964b48a63e898abbdf19f62024-12-11T08:17:17ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-012111239125010.1080/15476286.2024.2430817The role of SRP9/SRP14 in regulating Alu RNADaniel Gussakovsky0Nicole A. Black1Evan P. Booy2Sean A. McKenna3Department of Chemistry, University of Manitoba, Winnipeg, MB, CanadaDepartment of Chemistry, University of Manitoba, Winnipeg, MB, CanadaDepartment of Chemistry, University of Manitoba, Winnipeg, MB, CanadaDepartment of Chemistry, University of Manitoba, Winnipeg, MB, CanadaSRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL is mediated through a conserved structural motif that is shared with the primate-specific Alu RNA. Alu RNA are transcription products of Alu elements, a retroelement that comprises ~10% of the human genome. Alu RNA are involved in myriad biological processes and are dysregulated in several human disease states. This review focuses on the roles SRP9/SRP14 has in regulating Alu RNA diversification, maturation, and function. The diverse mechanisms through which SRP9/SRP14 regulates Alu RNA exemplify the breadth of protein-mediated regulation of non-coding RNA.https://www.tandfonline.com/doi/10.1080/15476286.2024.2430817SINEretrotranspositionscAlutranslationalternative splicingadenylation |
| spellingShingle | Daniel Gussakovsky Nicole A. Black Evan P. Booy Sean A. McKenna The role of SRP9/SRP14 in regulating Alu RNA RNA Biology SINE retrotransposition scAlu translation alternative splicing adenylation |
| title | The role of SRP9/SRP14 in regulating Alu RNA |
| title_full | The role of SRP9/SRP14 in regulating Alu RNA |
| title_fullStr | The role of SRP9/SRP14 in regulating Alu RNA |
| title_full_unstemmed | The role of SRP9/SRP14 in regulating Alu RNA |
| title_short | The role of SRP9/SRP14 in regulating Alu RNA |
| title_sort | role of srp9 srp14 in regulating alu rna |
| topic | SINE retrotransposition scAlu translation alternative splicing adenylation |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2430817 |
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