Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions
Recent evidence of vertical transmission of Tonate virus (TONV) during early pregnancy and its association with fetal neurological anomalies highlights its potential public health threat. TONV is an understudied alphavirus endemic to French Guiana. The growing presence of Aedes (Ae.) albopictus in E...
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Taylor & Francis Group
2025-08-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2025.2547733 |
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| author | Isabelle Moltini-Conclois Wipaporn Khanom Elliott F Miot Ai-rada Pintong Hermann Landry Munshili Njifon Carole Ginebre Valérie Choumet Bruno Coutard Cédric Mariac Pierre Roques Agathe M. G. Colmant Géraldine Piorkowski Julien Pompon Dorothée Missé |
| author_facet | Isabelle Moltini-Conclois Wipaporn Khanom Elliott F Miot Ai-rada Pintong Hermann Landry Munshili Njifon Carole Ginebre Valérie Choumet Bruno Coutard Cédric Mariac Pierre Roques Agathe M. G. Colmant Géraldine Piorkowski Julien Pompon Dorothée Missé |
| author_sort | Isabelle Moltini-Conclois |
| collection | DOAJ |
| description | Recent evidence of vertical transmission of Tonate virus (TONV) during early pregnancy and its association with fetal neurological anomalies highlights its potential public health threat. TONV is an understudied alphavirus endemic to French Guiana. The growing presence of Aedes (Ae.) albopictus in Europe raises concerns about its ability to transmit emerging arboviruses, including TONV. We assessed the vector competence of Ae. albopictus populations from mainland France and La Réunion Island via oral infections using different TONV doses. Both populations supported efficient viral replication, with infectious viral particles appearing in saliva by day 5 post-infection. Infection rate (IR), stepwise dissemination rate (sDR), and transmission efficiency (TE) increased with rising viral concentrations. At a viral concentration of 106 PFU/mL IR reached 80%, and TE at day 5 post-infection was 27% for the mainland strain and 37% for the La Réunion strain. Notably, TE declined over time in the mainland strain, while increasing progressively in the La Réunion population. Comparative infections with Chikungunya virus revealed that TONV was transmitted at similar or greater rates, confirming Ae. albopictus as a competent vector. Sequencing of mosquito organs revealed intra-host TONV genetic variability. A recurrent polymorphism at position 11,357 in the 3′UTR was detected in body tissues but not in heads of La Réunion mosquitoes, suggesting tissue-specific selection or bottlenecks. Our results demonstrate that Ae. albopictus from both tropical and temperate areas can efficiently transmit TONV and emphasize the importance of genomic surveillance to anticipate risk of its emergence in areas where this vector is established. |
| format | Article |
| id | doaj-art-e40dd475f47642e4bcc2ff3bf92d7823 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Taylor & Francis Group |
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| series | Emerging Microbes and Infections |
| spelling | doaj-art-e40dd475f47642e4bcc2ff3bf92d78232025-08-20T04:01:01ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512025-08-0110.1080/22221751.2025.2547733Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regionsIsabelle Moltini-Conclois0Wipaporn Khanom1Elliott F Miot2Ai-rada Pintong3Hermann Landry Munshili Njifon4Carole Ginebre5Valérie Choumet6Bruno Coutard7Cédric Mariac8Pierre Roques9Agathe M. G. Colmant10Géraldine Piorkowski11Julien Pompon12Dorothée Missé13MIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceAnnex of Garoua, Centre Pasteur of Cameroon, Garoua, CameroonMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceInstitut Pasteur, Environnement et Risques Infectieux, Université Paris Cité, FranceUnité Des Virus Emergents (UVE: Aix-Marseille Univ, Universita Di Corsica, IRD 190, Inserm 1207, IRBA), Marseille, FranceDIADE, Univ Montpellier, CIRAD, IRD, Montpellier, FranceVirology Unit, Institut Pasteur de Guinée, Conakry, GuineaUnité Des Virus Emergents (UVE: Aix-Marseille Univ, Universita Di Corsica, IRD 190, Inserm 1207, IRBA), Marseille, FranceUnité Des Virus Emergents (UVE: Aix-Marseille Univ, Universita Di Corsica, IRD 190, Inserm 1207, IRBA), Marseille, FranceMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceMIVEGEC, Univ. Montpellier, CNRS, IRD, Montpellier, FranceRecent evidence of vertical transmission of Tonate virus (TONV) during early pregnancy and its association with fetal neurological anomalies highlights its potential public health threat. TONV is an understudied alphavirus endemic to French Guiana. The growing presence of Aedes (Ae.) albopictus in Europe raises concerns about its ability to transmit emerging arboviruses, including TONV. We assessed the vector competence of Ae. albopictus populations from mainland France and La Réunion Island via oral infections using different TONV doses. Both populations supported efficient viral replication, with infectious viral particles appearing in saliva by day 5 post-infection. Infection rate (IR), stepwise dissemination rate (sDR), and transmission efficiency (TE) increased with rising viral concentrations. At a viral concentration of 106 PFU/mL IR reached 80%, and TE at day 5 post-infection was 27% for the mainland strain and 37% for the La Réunion strain. Notably, TE declined over time in the mainland strain, while increasing progressively in the La Réunion population. Comparative infections with Chikungunya virus revealed that TONV was transmitted at similar or greater rates, confirming Ae. albopictus as a competent vector. Sequencing of mosquito organs revealed intra-host TONV genetic variability. A recurrent polymorphism at position 11,357 in the 3′UTR was detected in body tissues but not in heads of La Réunion mosquitoes, suggesting tissue-specific selection or bottlenecks. Our results demonstrate that Ae. albopictus from both tropical and temperate areas can efficiently transmit TONV and emphasize the importance of genomic surveillance to anticipate risk of its emergence in areas where this vector is established.https://www.tandfonline.com/doi/10.1080/22221751.2025.2547733arbovirusTonate virusChikungunya virusAedes albopictusvector competence |
| spellingShingle | Isabelle Moltini-Conclois Wipaporn Khanom Elliott F Miot Ai-rada Pintong Hermann Landry Munshili Njifon Carole Ginebre Valérie Choumet Bruno Coutard Cédric Mariac Pierre Roques Agathe M. G. Colmant Géraldine Piorkowski Julien Pompon Dorothée Missé Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions Emerging Microbes and Infections arbovirus Tonate virus Chikungunya virus Aedes albopictus vector competence |
| title | Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions |
| title_full | Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions |
| title_fullStr | Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions |
| title_full_unstemmed | Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions |
| title_short | Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions |
| title_sort | vector competence of aedes albopictus for tonate virus highlights transmission risks in temperate and tropical regions |
| topic | arbovirus Tonate virus Chikungunya virus Aedes albopictus vector competence |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2025.2547733 |
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