Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study
Objective To explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to investigate dietary and lifestyle risk factors for gastric cancer in Fujian Province, China.Design A hospital-based, 1:1 matc...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-09-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e042341.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841554129294458880 |
|---|---|
| author | Lin Cai Wen Wang Ping Yuan Lan Lin Kuicheng Zheng Sihan Wu Liangxiang Huang Bingshan Wu Tiehui Chen Xiaoqing Li |
| author_facet | Lin Cai Wen Wang Ping Yuan Lan Lin Kuicheng Zheng Sihan Wu Liangxiang Huang Bingshan Wu Tiehui Chen Xiaoqing Li |
| author_sort | Lin Cai |
| collection | DOAJ |
| description | Objective To explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to investigate dietary and lifestyle risk factors for gastric cancer in Fujian Province, China.Design A hospital-based, 1:1 matched case–control study.Setting Patients with newly diagnosed gastric cancer were recruited from the Fujian Provincial Hospital and the No. 900 Hospital of the Joint Support Force of the Chinese People’s Liberation Army between July 2014 and December 2016.Participants A total of 180 pairs of patients with gastric cancer and control subjects were recruited in the study, including 134 (74.4%) male pairs and 46 (25.6%) female pairs.Investigation and analysis measures Serological indicators were tested with ELISA kits. Dietary, lifestyle and psychological factors were investigated through face-to-face questionnaire. Relationships between gastric cancer and these influencing factors were examined by Χ2 test and conditional logistic regression.Results Serum PG II and G-17 levels and H. pylori infection rate were higher in patients with gastric cancer than in control subjects (p<0.05), while PG I/II ratio was lower in patients with gastric cancer (p<0.05). Serum G-17 levels were higher in patients with corpus gastric cancer than in patients with antral gastric cancer (p<0.05). Serum PG II levels were higher in patients with advanced gastric cancer than in patients with early-stage cancer (p<0.05), however, PG I/II ratio was lower in patients with advanced-stage gastric cancer than in patients with early-stage cancer (p<0.05). Eating hot food (OR=2.32), eating pickled vegetables (OR=4.05) and often feel troubled (OR=2.21) were found to significantly increase the risk of gastric cancer (all p<0.05), while consuming onion or garlic (OR=0.35), drinking tea (OR=0.26), eating fresh fruits (OR=0.55), and high serum PG I (OR=0.99) or PG I/II ratio (OR=0.73) were found to be protective against gastric cancer.Conclusion Study results showed that serum PG, G-17 and H. pylori antibodies could be useful indicators for early diagnosis of gastric cancer. Increase in serum G-17 level might indicate the location of gastric cancer. Increase in serum PG II level and decrease in PG I/II ratio might imply the clinical stage. Eating hot food, eating pickled vegetables and often feel troubled may be risk factors for gastric cancer, while eating fresh fruits, eating onion or garlic, and drinking tea may be protective factors against the disease. |
| format | Article |
| id | doaj-art-e403b31abe3a4d79bb196bd4fc5a4cf8 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e403b31abe3a4d79bb196bd4fc5a4cf82025-01-08T21:15:10ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-042341Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control studyLin Cai0Wen Wang1Ping Yuan2Lan Lin3Kuicheng Zheng4Sihan Wu5Liangxiang Huang6Bingshan Wu7Tiehui Chen8Xiaoqing Li93 Department of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, ChinaGastroenterology, Fuzhou General Hospital of Nanjing Military Command Area, Fuzhou, Fujian, ChinaCardio-Pulmonary Circulation, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, ChinaChronic Disease Prevention, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, ChinaFujian Key Laboratory of Zoonoses Research, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, ChinaChronic Disease Prevention, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, ChinaGastrointestinal Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaFujian Key Laboratory of Zoonoses Research, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, ChinaChronic Disease Prevention, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, ChinaObjective To explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to investigate dietary and lifestyle risk factors for gastric cancer in Fujian Province, China.Design A hospital-based, 1:1 matched case–control study.Setting Patients with newly diagnosed gastric cancer were recruited from the Fujian Provincial Hospital and the No. 900 Hospital of the Joint Support Force of the Chinese People’s Liberation Army between July 2014 and December 2016.Participants A total of 180 pairs of patients with gastric cancer and control subjects were recruited in the study, including 134 (74.4%) male pairs and 46 (25.6%) female pairs.Investigation and analysis measures Serological indicators were tested with ELISA kits. Dietary, lifestyle and psychological factors were investigated through face-to-face questionnaire. Relationships between gastric cancer and these influencing factors were examined by Χ2 test and conditional logistic regression.Results Serum PG II and G-17 levels and H. pylori infection rate were higher in patients with gastric cancer than in control subjects (p<0.05), while PG I/II ratio was lower in patients with gastric cancer (p<0.05). Serum G-17 levels were higher in patients with corpus gastric cancer than in patients with antral gastric cancer (p<0.05). Serum PG II levels were higher in patients with advanced gastric cancer than in patients with early-stage cancer (p<0.05), however, PG I/II ratio was lower in patients with advanced-stage gastric cancer than in patients with early-stage cancer (p<0.05). Eating hot food (OR=2.32), eating pickled vegetables (OR=4.05) and often feel troubled (OR=2.21) were found to significantly increase the risk of gastric cancer (all p<0.05), while consuming onion or garlic (OR=0.35), drinking tea (OR=0.26), eating fresh fruits (OR=0.55), and high serum PG I (OR=0.99) or PG I/II ratio (OR=0.73) were found to be protective against gastric cancer.Conclusion Study results showed that serum PG, G-17 and H. pylori antibodies could be useful indicators for early diagnosis of gastric cancer. Increase in serum G-17 level might indicate the location of gastric cancer. Increase in serum PG II level and decrease in PG I/II ratio might imply the clinical stage. Eating hot food, eating pickled vegetables and often feel troubled may be risk factors for gastric cancer, while eating fresh fruits, eating onion or garlic, and drinking tea may be protective factors against the disease.https://bmjopen.bmj.com/content/10/9/e042341.full |
| spellingShingle | Lin Cai Wen Wang Ping Yuan Lan Lin Kuicheng Zheng Sihan Wu Liangxiang Huang Bingshan Wu Tiehui Chen Xiaoqing Li Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study BMJ Open |
| title | Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study |
| title_full | Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study |
| title_fullStr | Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study |
| title_full_unstemmed | Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study |
| title_short | Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study |
| title_sort | risk factors for gastric cancer and related serological levels in fujian china hospital based case control study |
| url | https://bmjopen.bmj.com/content/10/9/e042341.full |
| work_keys_str_mv | AT lincai riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT wenwang riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT pingyuan riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT lanlin riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT kuichengzheng riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT sihanwu riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT liangxianghuang riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT bingshanwu riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT tiehuichen riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy AT xiaoqingli riskfactorsforgastriccancerandrelatedserologicallevelsinfujianchinahospitalbasedcasecontrolstudy |