Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study
BackgroundPostoperative visceral pain is a common complication after endoscopic retrograde cholangiopancreatography (ERCP). In this study, we compared the analgesic and anti-inflammatory effects of oxycodone and fentanyl in children undergoing ERCP.MethodsA single-center, randomized, double-blind st...
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Frontiers Media S.A.
2025-01-01
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| author | Wei Ji Wei Ji Liping Sun Liping Sun Yue Huang Yue Huang Jie Bai Jie Bai Jijian Zheng Jijian Zheng Kan Zhang Kan Zhang |
| author_facet | Wei Ji Wei Ji Liping Sun Liping Sun Yue Huang Yue Huang Jie Bai Jie Bai Jijian Zheng Jijian Zheng Kan Zhang Kan Zhang |
| author_sort | Wei Ji |
| collection | DOAJ |
| description | BackgroundPostoperative visceral pain is a common complication after endoscopic retrograde cholangiopancreatography (ERCP). In this study, we compared the analgesic and anti-inflammatory effects of oxycodone and fentanyl in children undergoing ERCP.MethodsA single-center, randomized, double-blind study was conducted at a tertiary care hospital affiliated with Shanghai Jiao Tong University. Eighty-two pediatric patients aged 2–18 years who were scheduled for elective ERCP were randomly assigned to receive either oxycodone (0.2 mg/kg) or fentanyl (2 μg/kg). The postoperative pain was evaluated after 10 min, 20 min, and 30 min in the post-anesthesia care unit (PACU) as well as 6 h and 24 h in the ward following ERCP. Additionally, inflammatory cytokines in the serum, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 were examined by blood sampling at baseline, 6 h, and 24 h after ERCP.ResultsCompared to fentanyl, children receiving oxycodone had significantly lower pain scores at 30 min, 6 h, and 24 h after ERCP, while the scores at 10 and 20 min were similar in both groups. We also found that fewer patients had pain scores ≥3 at 6 h and 24 h after the procedure in the oxycodone group [36.6% (15/41) vs. 61.0% (25/41) at 6 h, 34.1% (14/41) vs. 58.5% (24/41) at 24 h, p = 0.027 for both cases]. Furthermore, fewer children in the oxycodone group had elevated inflammatory cytokines (IL-6 at 6 h and TNF-α at 24 h after ERCP) compared to the fentanyl group. The incidence of postoperative vomiting was also lower among children receiving oxycodone [14.1% (7/41) vs. 24.4% (10/41), p = 0.032].ConclusionOxycodone (0.2 mg kg−1) can provide effective analgesia and stable hemodynamics in children undergoing ERCP. This analgesic characteristic may be related to amelioration of inflammation after ERCP.Clinical Trial Registrationwww.chictr.org.cn, identifier ChiCTR2300074473. |
| format | Article |
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| spelling | doaj-art-e3f4aa3043b448f59a71d0f2de0f7d932025-01-08T06:12:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15155011515501Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel studyWei Ji0Wei Ji1Liping Sun2Liping Sun3Yue Huang4Yue Huang5Jie Bai6Jie Bai7Jijian Zheng8Jijian Zheng9Kan Zhang10Kan Zhang11Department of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children’s Medical Center, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Children’s Medical Center, Shanghai, ChinaDepartment of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children’s Medical Center, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Children’s Medical Center, Shanghai, ChinaDepartment of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children’s Medical Center, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Children’s Medical Center, Shanghai, ChinaDepartment of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children’s Medical Center, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Children’s Medical Center, Shanghai, ChinaDepartment of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children’s Medical Center, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Children’s Medical Center, Shanghai, ChinaDepartment of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children’s Medical Center, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Children’s Medical Center, Shanghai, ChinaBackgroundPostoperative visceral pain is a common complication after endoscopic retrograde cholangiopancreatography (ERCP). In this study, we compared the analgesic and anti-inflammatory effects of oxycodone and fentanyl in children undergoing ERCP.MethodsA single-center, randomized, double-blind study was conducted at a tertiary care hospital affiliated with Shanghai Jiao Tong University. Eighty-two pediatric patients aged 2–18 years who were scheduled for elective ERCP were randomly assigned to receive either oxycodone (0.2 mg/kg) or fentanyl (2 μg/kg). The postoperative pain was evaluated after 10 min, 20 min, and 30 min in the post-anesthesia care unit (PACU) as well as 6 h and 24 h in the ward following ERCP. Additionally, inflammatory cytokines in the serum, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 were examined by blood sampling at baseline, 6 h, and 24 h after ERCP.ResultsCompared to fentanyl, children receiving oxycodone had significantly lower pain scores at 30 min, 6 h, and 24 h after ERCP, while the scores at 10 and 20 min were similar in both groups. We also found that fewer patients had pain scores ≥3 at 6 h and 24 h after the procedure in the oxycodone group [36.6% (15/41) vs. 61.0% (25/41) at 6 h, 34.1% (14/41) vs. 58.5% (24/41) at 24 h, p = 0.027 for both cases]. Furthermore, fewer children in the oxycodone group had elevated inflammatory cytokines (IL-6 at 6 h and TNF-α at 24 h after ERCP) compared to the fentanyl group. The incidence of postoperative vomiting was also lower among children receiving oxycodone [14.1% (7/41) vs. 24.4% (10/41), p = 0.032].ConclusionOxycodone (0.2 mg kg−1) can provide effective analgesia and stable hemodynamics in children undergoing ERCP. This analgesic characteristic may be related to amelioration of inflammation after ERCP.Clinical Trial Registrationwww.chictr.org.cn, identifier ChiCTR2300074473.https://www.frontiersin.org/articles/10.3389/fphar.2024.1515501/fulloxycodoneendoscopic retrograde cholangiopancreatography (ERCP)visceral painchildreninflammation |
| spellingShingle | Wei Ji Wei Ji Liping Sun Liping Sun Yue Huang Yue Huang Jie Bai Jie Bai Jijian Zheng Jijian Zheng Kan Zhang Kan Zhang Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study Frontiers in Pharmacology oxycodone endoscopic retrograde cholangiopancreatography (ERCP) visceral pain children inflammation |
| title | Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study |
| title_full | Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study |
| title_fullStr | Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study |
| title_full_unstemmed | Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study |
| title_short | Oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography: a randomized, double-blind, parallel study |
| title_sort | oxycodone for analgesia in children undergoing endoscopic retrograde cholangiopancreatography a randomized double blind parallel study |
| topic | oxycodone endoscopic retrograde cholangiopancreatography (ERCP) visceral pain children inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1515501/full |
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