In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP). Resistance to CZA is frequently linked to point mutations in the blaKPC. We conducted in vitro simulations of in vivo blaKPC mutations using CZA. Fo...

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Bibliographic Details
Main Authors: Siquan Shen, Chengkang Tang, Weiwei Yang, Li Ding, Renru Han, Qingyu Shi, Yan Guo, Dandan Yin, Fupin Hu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Ceftazidime-avibactam
Klebsiella pneumoniae
KPC variants
induction
in vitro mimicry
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2356146
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