Microbial phenolic metabolites are associated with better frontal lobe cognition
With increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets, such as the Mediterranean diet, which is particularly rich in polyphenols, bioactive compounds with neuroprotective p...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250013 |
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| author | Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Castañer Ramon Estruch Emili Ros Rosa M. Lamuela-Raventós |
| author_facet | Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Castañer Ramon Estruch Emili Ros Rosa M. Lamuela-Raventós |
| author_sort | Inés Domínguez-López |
| collection | DOAJ |
| description | With increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets, such as the Mediterranean diet, which is particularly rich in polyphenols, bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid, enterodiol glucuronide, enterolactone glucuronide, urolithin B glucuronide, and vanillic acid glucuronide), and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM, and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites, vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population. |
| format | Article |
| id | doaj-art-e3d914853bcc4e9f86f4614afa04dbc3 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-e3d914853bcc4e9f86f4614afa04dbc32025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363266327210.26599/FSHW.2023.9250013Microbial phenolic metabolites are associated with better frontal lobe cognitionInés Domínguez-López0Isabella Parilli-Moser1Anna Vallverdú-Queralt2Anna Tresserra-Rimbau3Cinta Valls-Pedret4Zenaida Vázquez-Ruiz5Olga Castañer6Ramon Estruch7Emili Ros8Rosa M. Lamuela-Raventós9Departament de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmacia, Universitat de Barcelon (UB), Barcelona 08028, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmacia, Universitat de Barcelon (UB), Barcelona 08028, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmacia, Universitat de Barcelon (UB), Barcelona 08028, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmacia, Universitat de Barcelon (UB), Barcelona 08028, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos Ⅲ, Madrid 28029, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos Ⅲ, Madrid 28029, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos Ⅲ, Madrid 28029, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos Ⅲ, Madrid 28029, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos Ⅲ, Madrid 28029, SpainDepartament de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmacia, Universitat de Barcelon (UB), Barcelona 08028, SpainWith increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets, such as the Mediterranean diet, which is particularly rich in polyphenols, bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid, enterodiol glucuronide, enterolactone glucuronide, urolithin B glucuronide, and vanillic acid glucuronide), and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM, and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites, vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.https://www.sciopen.com/article/10.26599/FSHW.2023.9250013polyphenolsneurodegenerationmicrobiotagut-brain axispredimed |
| spellingShingle | Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Castañer Ramon Estruch Emili Ros Rosa M. Lamuela-Raventós Microbial phenolic metabolites are associated with better frontal lobe cognition Food Science and Human Wellness polyphenols neurodegeneration microbiota gut-brain axis predimed |
| title | Microbial phenolic metabolites are associated with better frontal lobe cognition |
| title_full | Microbial phenolic metabolites are associated with better frontal lobe cognition |
| title_fullStr | Microbial phenolic metabolites are associated with better frontal lobe cognition |
| title_full_unstemmed | Microbial phenolic metabolites are associated with better frontal lobe cognition |
| title_short | Microbial phenolic metabolites are associated with better frontal lobe cognition |
| title_sort | microbial phenolic metabolites are associated with better frontal lobe cognition |
| topic | polyphenols neurodegeneration microbiota gut-brain axis predimed |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250013 |
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