Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus
A fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using RT-qPCR and ELISA. A high IL-6 titer, low IL-...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Virology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fviro.2024.1498672/full |
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| author | Moufid Mhamadi Moufid Mhamadi Ousseynou Sene Arfang Diamanka Moundhir Mhamadi Marie Pedapa Mendy Andy Mahine Diouf Mignane Ndiaye Mamadou Aliou Barry Samba Niang Sagne Mahfouz Cissé Traoré Amadou Alpha Sall Gamou Fall Ndongo Dia Oumar Faye |
| author_facet | Moufid Mhamadi Moufid Mhamadi Ousseynou Sene Arfang Diamanka Moundhir Mhamadi Marie Pedapa Mendy Andy Mahine Diouf Mignane Ndiaye Mamadou Aliou Barry Samba Niang Sagne Mahfouz Cissé Traoré Amadou Alpha Sall Gamou Fall Ndongo Dia Oumar Faye |
| author_sort | Moufid Mhamadi |
| collection | DOAJ |
| description | A fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using RT-qPCR and ELISA. A high IL-6 titer, low IL-10 titer, and delayed IgG response were associated with disease severity. These biomarkers may serve as predictors of disease severity, potentially aiding in early intervention and treatment strategies. |
| format | Article |
| id | doaj-art-e3d726e779f9446d93c2479c820d3b6e |
| institution | Kabale University |
| issn | 2673-818X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Virology |
| spelling | doaj-art-e3d726e779f9446d93c2479c820d3b6e2025-01-07T05:24:04ZengFrontiers Media S.A.Frontiers in Virology2673-818X2025-01-01410.3389/fviro.2024.14986721498672Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virusMoufid Mhamadi0Moufid Mhamadi1Ousseynou Sene2Arfang Diamanka3Moundhir Mhamadi4Marie Pedapa Mendy5Andy Mahine Diouf6Mignane Ndiaye7Mamadou Aliou Barry8Samba Niang Sagne9Mahfouz Cissé Traoré10Amadou Alpha Sall11Gamou Fall12Ndongo Dia13Oumar Faye14Virology Department, Institut Pasteur de Dakar, Dakar, SenegalVaccine Research Center, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalDepartment of Animal Biology, Université Cheikh Anta Diop de Dakar, Dakar, SenegalDiatropix, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalEpidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar, SenegalEpidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalVirology Department, Institut Pasteur de Dakar, Dakar, SenegalA fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using RT-qPCR and ELISA. A high IL-6 titer, low IL-10 titer, and delayed IgG response were associated with disease severity. These biomarkers may serve as predictors of disease severity, potentially aiding in early intervention and treatment strategies.https://www.frontiersin.org/articles/10.3389/fviro.2024.1498672/fullCCHFVbiomarkersviremiaimmunoglobulinscytokinesseverity |
| spellingShingle | Moufid Mhamadi Moufid Mhamadi Ousseynou Sene Arfang Diamanka Moundhir Mhamadi Marie Pedapa Mendy Andy Mahine Diouf Mignane Ndiaye Mamadou Aliou Barry Samba Niang Sagne Mahfouz Cissé Traoré Amadou Alpha Sall Gamou Fall Ndongo Dia Oumar Faye Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus Frontiers in Virology CCHFV biomarkers viremia immunoglobulins cytokines severity |
| title | Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus |
| title_full | Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus |
| title_fullStr | Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus |
| title_full_unstemmed | Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus |
| title_short | Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus |
| title_sort | case report kinetics of viral load immunoglobulins and cytokines in a fatal case of crimean congo hemorrhagic fever virus |
| topic | CCHFV biomarkers viremia immunoglobulins cytokines severity |
| url | https://www.frontiersin.org/articles/10.3389/fviro.2024.1498672/full |
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