Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment
<b>Background:</b> The human digestive system contains approximately 100 trillion bacteria. The gut microbiota is an emerging field of research that is associated with specific biological processes in many diseases, including cardiovascular disease, obesity, diabetes, brain disease, rheu...
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2024-12-01
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| author | Rashid Mir Shrooq A. Albarqi Wed Albalawi Hanan E. Alatwi Marfat Alatawy Ruqaiah I. Bedaiwi Reema Almotairi Eram Husain Mohammad Zubair Ghaida Alanazi Shouq S. Alsubaie Razan I. Alghabban Khalid A. Alfifi Shabnam Bashir |
| author_facet | Rashid Mir Shrooq A. Albarqi Wed Albalawi Hanan E. Alatwi Marfat Alatawy Ruqaiah I. Bedaiwi Reema Almotairi Eram Husain Mohammad Zubair Ghaida Alanazi Shouq S. Alsubaie Razan I. Alghabban Khalid A. Alfifi Shabnam Bashir |
| author_sort | Rashid Mir |
| collection | DOAJ |
| description | <b>Background:</b> The human digestive system contains approximately 100 trillion bacteria. The gut microbiota is an emerging field of research that is associated with specific biological processes in many diseases, including cardiovascular disease, obesity, diabetes, brain disease, rheumatoid arthritis, and cancer. Emerging evidence indicates that the gut microbiota affects the response to anticancer therapies by modulating the host immune system. Recent studies have explained a high correlation between the gut microbiota and breast cancer: dysbiosis in breast cancer may regulate the systemic inflammatory response, hormone metabolism, immune response, and the tumor microenvironment. Some of the gut bacteria are related to estrogen metabolism, which may increase or decrease the risk of breast cancer by changing the number of hormones. Further, the gut microbiota has been seen to modulate the immune system in respect of its ability to protect against and treat cancers, with a specific focus on hormone receptor-positive breast cancer. Probiotics and other therapies claiming to control the gut microbiome by bacterial means might be useful in the prevention, or even in the treatment, of breast cancer. <b>Conclusions:</b> The present review underlines the various aspects of gut microbiota in breast cancer risk and its clinical application, warranting research on individualized microbiome-modulated therapeutic approaches to breast cancer treatment. |
| format | Article |
| id | doaj-art-e3a765580f0f4300a1b82aebed609e9f |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-e3a765580f0f4300a1b82aebed609e9f2024-12-27T14:39:33ZengMDPI AGMetabolites2218-19892024-12-01141268310.3390/metabo14120683Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in TreatmentRashid Mir0Shrooq A. Albarqi1Wed Albalawi2Hanan E. Alatwi3Marfat Alatawy4Ruqaiah I. Bedaiwi5Reema Almotairi6Eram Husain7Mohammad Zubair8Ghaida Alanazi9Shouq S. Alsubaie10Razan I. Alghabban11Khalid A. Alfifi12Shabnam Bashir13Department of Medical Lab Technology, Faculty of Applied Medical Sciences, Prince Fahd Bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk 47713, Saudi ArabiaMolecular Medicine, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi ArabiaMolecular Medicine, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, Prince Fahd Bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, Prince Fahd Bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, Prince Fahd Bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk 47713, Saudi ArabiaMolecular Medicine, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi ArabiaMolecular Medicine, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi ArabiaMolecular Medicine, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi ArabiaDepartment of Laboratory and Blood Bank, King Fahd Special Hospital, Tabuk 47717, Saudi ArabiaMubarak Hospital, Srinagar 190002, Jammu and Kashmir, India<b>Background:</b> The human digestive system contains approximately 100 trillion bacteria. The gut microbiota is an emerging field of research that is associated with specific biological processes in many diseases, including cardiovascular disease, obesity, diabetes, brain disease, rheumatoid arthritis, and cancer. Emerging evidence indicates that the gut microbiota affects the response to anticancer therapies by modulating the host immune system. Recent studies have explained a high correlation between the gut microbiota and breast cancer: dysbiosis in breast cancer may regulate the systemic inflammatory response, hormone metabolism, immune response, and the tumor microenvironment. Some of the gut bacteria are related to estrogen metabolism, which may increase or decrease the risk of breast cancer by changing the number of hormones. Further, the gut microbiota has been seen to modulate the immune system in respect of its ability to protect against and treat cancers, with a specific focus on hormone receptor-positive breast cancer. Probiotics and other therapies claiming to control the gut microbiome by bacterial means might be useful in the prevention, or even in the treatment, of breast cancer. <b>Conclusions:</b> The present review underlines the various aspects of gut microbiota in breast cancer risk and its clinical application, warranting research on individualized microbiome-modulated therapeutic approaches to breast cancer treatment.https://www.mdpi.com/2218-1989/14/12/683gut microbiotabreast cancerdysbiosishormone metabolismcancer immunotherapy |
| spellingShingle | Rashid Mir Shrooq A. Albarqi Wed Albalawi Hanan E. Alatwi Marfat Alatawy Ruqaiah I. Bedaiwi Reema Almotairi Eram Husain Mohammad Zubair Ghaida Alanazi Shouq S. Alsubaie Razan I. Alghabban Khalid A. Alfifi Shabnam Bashir Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment Metabolites gut microbiota breast cancer dysbiosis hormone metabolism cancer immunotherapy |
| title | Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment |
| title_full | Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment |
| title_fullStr | Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment |
| title_full_unstemmed | Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment |
| title_short | Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment |
| title_sort | emerging role of gut microbiota in breast cancer development and its implications in treatment |
| topic | gut microbiota breast cancer dysbiosis hormone metabolism cancer immunotherapy |
| url | https://www.mdpi.com/2218-1989/14/12/683 |
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