Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

Abstract Background After myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial dysfunction. Direct reprogramming of fibroblasts into cardiomyocytes via the forced overexpression of cardiac transcription factors Gata4, Mef2c, and Tb...

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Main Authors: Juntao Fang, Qiangbing Yang, Renée G. C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Stem Cell Research & Therapy
Subjects:
Vitamin C
Cardiac reprogramming
ROS
Cardiac regeneration
Online Access:https://doi.org/10.1186/s13287-023-03615-x
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