Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers

Abstract TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted therapy yet exists. Protein arginine methyltransferase 5 (PRMT5), an enzyme which catalyzes the methylation of arginines on histone and non‐histone proteins, has...

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Bibliographic Details
Main Authors: Mathilde Vinet, Samyuktha Suresh, Virginie Maire, Clarisse Monchecourt, Fariba Némati, Laetitia Lesage, Fabienne Pierre, Mengliang Ye, Auriane Lescure, Amélie Brisson, Didier Meseure, André Nicolas, Guillem Rigaill, Elisabetta Marangoni, Elaine Del Nery, Sergio Roman‐Roman, Thierry Dubois
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
breast cancer
molecular biology
targeted therapy
translational research
Online Access:https://doi.org/10.1002/cam4.2114
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