Current concept on pediatric low-grade glioma in the era of molecular diagnosis
Central nervous system tumors are the most common solid tumors and the second leading cause of cancer-related deaths among pediatric patients. Despite recent advances in surgical technique, chemotherapy, and radiotherapy, it disappointedly relates to significantly profound morbidity compared to othe...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Tungs’ Medical Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.4103/ETMJ.ETMJ-D-24-00016 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525500695019520 |
|---|---|
| author | Tzu-Chiang Peng Ching-Ying Wang Yi-Yen Lee |
| author_facet | Tzu-Chiang Peng Ching-Ying Wang Yi-Yen Lee |
| author_sort | Tzu-Chiang Peng |
| collection | DOAJ |
| description | Central nervous system tumors are the most common solid tumors and the second leading cause of cancer-related deaths among pediatric patients. Despite recent advances in surgical technique, chemotherapy, and radiotherapy, it disappointedly relates to significantly profound morbidity compared to other cancers. The current therapeutic strategy leads to a high incidence of adverse effects. Pediatric brain tumor survivors have a higher risk of neurocognitive decline and endocrine, neurological, and social domain impairment than the age-matched group. A recent study has made a meaningful progress in the field of genetics and shed light on the broad molecular heterogeneity of pediatric brain tumors. This insight has impacted the current clinical practice and opened an avenue to potential therapeutic choice. Here, we reviewed the progress in the understanding of pediatric low-grade glioma and emerging target therapy. |
| format | Article |
| id | doaj-art-e37c35cba324488798204c7ff7c4a7e9 |
| institution | Kabale University |
| issn | 2071-3592 2949-9720 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tungs’ Medical Journal |
| spelling | doaj-art-e37c35cba324488798204c7ff7c4a7e92025-01-17T10:57:17ZengWolters Kluwer Medknow PublicationsTungs’ Medical Journal2071-35922949-97202024-12-01182455410.4103/ETMJ.ETMJ-D-24-00016Current concept on pediatric low-grade glioma in the era of molecular diagnosisTzu-Chiang PengChing-Ying WangYi-Yen LeeCentral nervous system tumors are the most common solid tumors and the second leading cause of cancer-related deaths among pediatric patients. Despite recent advances in surgical technique, chemotherapy, and radiotherapy, it disappointedly relates to significantly profound morbidity compared to other cancers. The current therapeutic strategy leads to a high incidence of adverse effects. Pediatric brain tumor survivors have a higher risk of neurocognitive decline and endocrine, neurological, and social domain impairment than the age-matched group. A recent study has made a meaningful progress in the field of genetics and shed light on the broad molecular heterogeneity of pediatric brain tumors. This insight has impacted the current clinical practice and opened an avenue to potential therapeutic choice. Here, we reviewed the progress in the understanding of pediatric low-grade glioma and emerging target therapy.https://doi.org/10.4103/ETMJ.ETMJ-D-24-00016brain tumorchildrenmolecular diagnosispediatric low-grade gliomaprecision medicinetarget therapy |
| spellingShingle | Tzu-Chiang Peng Ching-Ying Wang Yi-Yen Lee Current concept on pediatric low-grade glioma in the era of molecular diagnosis Tungs’ Medical Journal brain tumor children molecular diagnosis pediatric low-grade glioma precision medicine target therapy |
| title | Current concept on pediatric low-grade glioma in the era of molecular diagnosis |
| title_full | Current concept on pediatric low-grade glioma in the era of molecular diagnosis |
| title_fullStr | Current concept on pediatric low-grade glioma in the era of molecular diagnosis |
| title_full_unstemmed | Current concept on pediatric low-grade glioma in the era of molecular diagnosis |
| title_short | Current concept on pediatric low-grade glioma in the era of molecular diagnosis |
| title_sort | current concept on pediatric low grade glioma in the era of molecular diagnosis |
| topic | brain tumor children molecular diagnosis pediatric low-grade glioma precision medicine target therapy |
| url | https://doi.org/10.4103/ETMJ.ETMJ-D-24-00016 |
| work_keys_str_mv | AT tzuchiangpeng currentconceptonpediatriclowgradegliomaintheeraofmoleculardiagnosis AT chingyingwang currentconceptonpediatriclowgradegliomaintheeraofmoleculardiagnosis AT yiyenlee currentconceptonpediatriclowgradegliomaintheeraofmoleculardiagnosis |