Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases.

Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases.

Genome-wide association studies (GWAS) provide valuable insights into the genetic architecture of complex traits, yet interpreting their results remains challenging due to the polygenic nature of most traits. Gene set analysis offers a solution by aggregating genetic variants into biologically relev...

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Main Authors: Tahereh Gholipourshahraki, Zhonghao Bai, Merina Shrestha, Astrid Hjelholt, Sile Hu, Mads Kjolby, Palle Duun Rohde, Peter Sørensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011463
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