Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia
Background. Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insu...
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ASEAN Federation of Endocrine Societies
2024-08-01
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| Series: | Journal of the ASEAN Federation of Endocrine Societies |
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| Online Access: | https://asean-endocrinejournal.org/index.php/JAFES/article/view/3015 |
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| author | I Made Pande Dwipayana Wira Gotera Made Ratna Saraswati I Made Siswadi Semadi Ida Bagus Aditya Nugraha Ketut Suastika Anak Agung Gde Budhiarta Padma Amrita Wahyu Pratama Putra |
| author_facet | I Made Pande Dwipayana Wira Gotera Made Ratna Saraswati I Made Siswadi Semadi Ida Bagus Aditya Nugraha Ketut Suastika Anak Agung Gde Budhiarta Padma Amrita Wahyu Pratama Putra |
| author_sort | I Made Pande Dwipayana |
| collection | DOAJ |
| description |
Background. Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insulin-like growth factor 1 (IGF-1). Increased cancer risk is also associated with increased adipose tissue, such as in abdominal obesity, due to the higher risk of insulin resistance and hyperinsulinemia. Waist circumference is a parameter that indicates an individual's level of adiposity. In addition, the risk of cancer also increases in the elderly as they age. This study aims to assess the correlation between waist circumference and IGF-1 levels in the elderly population in Bali, Indonesia.
Methodology. This study used a cross-sectional analytical design conducted in the Melinggih Village, Gianyar Regency. The study was conducted in September 2023. This study has been approved by the Research Ethics Commission number 2020/UN14.2.2.VII.14/LT/2023. The study population included elderly individuals residing in the Melinggih Village who were willing to participate. Data analysis encompassed descriptive analysis and the Spearman correlation test.
Result. A total of 88 subjects participated in the study, consisting of 57 females (64.8%) and 31 males (35.2%).
A statistically significant but weak correlation coexists between waist circumference and IGF-1 levels.
Conclusion. A weak but statistically significant positive correlation was found between waist circumference and IGF-1 levels in the elderly. However, because of the small sample size, another study with a bigger sample size with enough power to investigate this association needs to be done to validate the results of the current study.
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| format | Article |
| id | doaj-art-e3360459630c47e5ab8ebe6360eb7e1a |
| institution | Kabale University |
| issn | 0857-1074 2308-118X |
| language | English |
| publishDate | 2024-08-01 |
| publisher | ASEAN Federation of Endocrine Societies |
| record_format | Article |
| series | Journal of the ASEAN Federation of Endocrine Societies |
| spelling | doaj-art-e3360459630c47e5ab8ebe6360eb7e1a2024-11-20T13:08:37ZengASEAN Federation of Endocrine SocietiesJournal of the ASEAN Federation of Endocrine Societies0857-10742308-118X2024-08-0139210.15605/jafes.039.02.15Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, IndonesiaI Made Pande Dwipayana0https://orcid.org/0000-0002-9836-6515Wira Gotera1Made Ratna Saraswati2I Made Siswadi Semadi3Ida Bagus Aditya Nugraha4https://orcid.org/0000-0002-0956-5126Ketut Suastika5https://orcid.org/0000-0001-7895-382XAnak Agung Gde Budhiarta6Padma Amrita7Wahyu Pratama Putra8Udayana UniversityUdayana UniversityUdayana UniversityUdayana UniversityUdayana UniversityUdayana UniversityUdayana UniversityUdayana UniversityUdayana University Background. Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insulin-like growth factor 1 (IGF-1). Increased cancer risk is also associated with increased adipose tissue, such as in abdominal obesity, due to the higher risk of insulin resistance and hyperinsulinemia. Waist circumference is a parameter that indicates an individual's level of adiposity. In addition, the risk of cancer also increases in the elderly as they age. This study aims to assess the correlation between waist circumference and IGF-1 levels in the elderly population in Bali, Indonesia. Methodology. This study used a cross-sectional analytical design conducted in the Melinggih Village, Gianyar Regency. The study was conducted in September 2023. This study has been approved by the Research Ethics Commission number 2020/UN14.2.2.VII.14/LT/2023. The study population included elderly individuals residing in the Melinggih Village who were willing to participate. Data analysis encompassed descriptive analysis and the Spearman correlation test. Result. A total of 88 subjects participated in the study, consisting of 57 females (64.8%) and 31 males (35.2%). A statistically significant but weak correlation coexists between waist circumference and IGF-1 levels. Conclusion. A weak but statistically significant positive correlation was found between waist circumference and IGF-1 levels in the elderly. However, because of the small sample size, another study with a bigger sample size with enough power to investigate this association needs to be done to validate the results of the current study. https://asean-endocrinejournal.org/index.php/JAFES/article/view/3015elderlyIGF-1waist circumference |
| spellingShingle | I Made Pande Dwipayana Wira Gotera Made Ratna Saraswati I Made Siswadi Semadi Ida Bagus Aditya Nugraha Ketut Suastika Anak Agung Gde Budhiarta Padma Amrita Wahyu Pratama Putra Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia Journal of the ASEAN Federation of Endocrine Societies elderly IGF-1 waist circumference |
| title | Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia |
| title_full | Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia |
| title_fullStr | Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia |
| title_full_unstemmed | Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia |
| title_short | Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia |
| title_sort | correlation between waist circumference and igf 1 levels in an elderly population in bali indonesia |
| topic | elderly IGF-1 waist circumference |
| url | https://asean-endocrinejournal.org/index.php/JAFES/article/view/3015 |
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