Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates of these efflux systems. In this work, we aim...
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Main Authors: | Léna Mazza, Alexandre Bory, Alexandre Luscher, Joachim Kloehn, Jean-Luc Wolfender, Christian van Delden, Thilo Köhler |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2025-01-01
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Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1512472/full |
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