Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study
BackgroundThis study examines the indirect causal relationships between dietary habits and osteoporosis, mediated through liposomes, utilizing a two-sample Mendelian randomization (MR) approach. The research leverages genetic variations as instrumental variables to explore the genetic influences on...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1389896/full |
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| author | Kehan Long Tengfei Zheng Ao Gong Zhendong Ying Lei Zhang |
| author_facet | Kehan Long Tengfei Zheng Ao Gong Zhendong Ying Lei Zhang |
| author_sort | Kehan Long |
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| description | BackgroundThis study examines the indirect causal relationships between dietary habits and osteoporosis, mediated through liposomes, utilizing a two-sample Mendelian randomization (MR) approach. The research leverages genetic variations as instrumental variables to explore the genetic influences on dietary habits, liposomes, and osteoporosis, aiming to unravel the complex interplay between diet, lipid metabolism, and bone health.MethodsThe study utilized genome-wide association studies (GWAS) data for liposomes from Finnish individuals and osteoporosis-related data, alongside dietary factors from the OpenGWAS database. Instrumental variables were selected based on genetic variants associated with these factors, using a strict significance level and linkage disequilibrium threshold. Statistical analysis employed the Inverse Variance Weighted method, weighted median, and mode-based methods within the R environment, complemented by sensitivity analyses to ensure the robustness of the causal inferences.ResultsFindings revealed significant causal relationships between specific dietary components (white rice, cereal, and non-oily fish) and osteoporosis risk, both directly and mediated through changes in liposome levels. Notably, white rice consumption was associated with an increased risk of osteoporosis, while cereal and non-oily fish intake showed protective effects. Further, certain liposomes were identified as mediators in these relationships, suggesting a link between diet, lipid profiles, and bone health.ConclusionThe study highlights the significant impact of dietary habits on osteoporosis risk, mediated through liposomes. These findings underscore the importance of considering lipidomic profiles in dietary guidance and suggest potential targets for preventing osteoporosis through nutritional interventions. |
| format | Article |
| id | doaj-art-e31b6ba9170842ddab4a3e7b0f532146 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-e31b6ba9170842ddab4a3e7b0f5321462024-12-13T11:03:32ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-10-011110.3389/fnut.2024.13898961389896Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization studyKehan Long0Tengfei Zheng1Ao Gong2Zhendong Ying3Lei Zhang4Department of Orthopedics, The Third Hospital of Mianyang-Sichuan Mental Health Center, Mianyang, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, Shandong, ChinaSecond Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSecond Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaThe First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaBackgroundThis study examines the indirect causal relationships between dietary habits and osteoporosis, mediated through liposomes, utilizing a two-sample Mendelian randomization (MR) approach. The research leverages genetic variations as instrumental variables to explore the genetic influences on dietary habits, liposomes, and osteoporosis, aiming to unravel the complex interplay between diet, lipid metabolism, and bone health.MethodsThe study utilized genome-wide association studies (GWAS) data for liposomes from Finnish individuals and osteoporosis-related data, alongside dietary factors from the OpenGWAS database. Instrumental variables were selected based on genetic variants associated with these factors, using a strict significance level and linkage disequilibrium threshold. Statistical analysis employed the Inverse Variance Weighted method, weighted median, and mode-based methods within the R environment, complemented by sensitivity analyses to ensure the robustness of the causal inferences.ResultsFindings revealed significant causal relationships between specific dietary components (white rice, cereal, and non-oily fish) and osteoporosis risk, both directly and mediated through changes in liposome levels. Notably, white rice consumption was associated with an increased risk of osteoporosis, while cereal and non-oily fish intake showed protective effects. Further, certain liposomes were identified as mediators in these relationships, suggesting a link between diet, lipid profiles, and bone health.ConclusionThe study highlights the significant impact of dietary habits on osteoporosis risk, mediated through liposomes. These findings underscore the importance of considering lipidomic profiles in dietary guidance and suggest potential targets for preventing osteoporosis through nutritional interventions.https://www.frontiersin.org/articles/10.3389/fnut.2024.1389896/fullosteoporosisdietary habitsliposomesMendelian randomizationGWAScausal inference |
| spellingShingle | Kehan Long Tengfei Zheng Ao Gong Zhendong Ying Lei Zhang Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study Frontiers in Nutrition osteoporosis dietary habits liposomes Mendelian randomization GWAS causal inference |
| title | Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study |
| title_full | Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study |
| title_fullStr | Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study |
| title_full_unstemmed | Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study |
| title_short | Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study |
| title_sort | genetic insights into dietary patterns liposome mediation and osteoporosis risk a mendelian randomization study |
| topic | osteoporosis dietary habits liposomes Mendelian randomization GWAS causal inference |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1389896/full |
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