A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis
Abstract A novel acidic deep eutectic solvent (ADES) has been developed as an efficient and sustainable alternative to traditional solvents and catalysts in organic synthesis. The ADES was synthesized through a simple one-pot procedure involving benzyl chloride, 2-(dimethylamino)ethanol, and p-tolue...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-07279-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849334816902742016 |
|---|---|
| author | Fatemeh Mohammad Najmedin Azizi Zohreh Mirjafari Javad Mokhtari |
| author_facet | Fatemeh Mohammad Najmedin Azizi Zohreh Mirjafari Javad Mokhtari |
| author_sort | Fatemeh Mohammad |
| collection | DOAJ |
| description | Abstract A novel acidic deep eutectic solvent (ADES) has been developed as an efficient and sustainable alternative to traditional solvents and catalysts in organic synthesis. The ADES was synthesized through a simple one-pot procedure involving benzyl chloride, 2-(dimethylamino)ethanol, and p-toluenesulfonic acid, yielding a homogeneous liquid. Structural and compositional characterization was performed using FTIR and NMR spectroscopy. The catalytic performance of the synthesized ADES was evaluated in the Pechmann condensation for the synthesis of coumarins. The reaction proceeded under mild conditions using commercially available starting materials, with reaction times ranging from 5 to 200 min and isolated yields between 72% and 97%. The process is operationally simple and readily scalable, indicating its suitability for industrial implementation. Importantly, the ADES demonstrated excellent recyclability, maintaining catalytic activity over five consecutive cycles without significant loss of efficiency which makes it an environmentally friendly and economically viable option for large-scale synthesis. |
| format | Article |
| id | doaj-art-e3073f63e6cb4e87b32dba59fbbf3d17 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e3073f63e6cb4e87b32dba59fbbf3d172025-08-20T03:45:28ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-07279-wA novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesisFatemeh Mohammad0Najmedin Azizi1Zohreh Mirjafari2Javad Mokhtari3Department of Chemistry, Science and Research Branch, Islamic Azad UniversityChemistry and Chemical Engineering Research Center of IranDepartment of Chemistry, Science and Research Branch, Islamic Azad UniversityDepartment of Chemistry, Science and Research Branch, Islamic Azad UniversityAbstract A novel acidic deep eutectic solvent (ADES) has been developed as an efficient and sustainable alternative to traditional solvents and catalysts in organic synthesis. The ADES was synthesized through a simple one-pot procedure involving benzyl chloride, 2-(dimethylamino)ethanol, and p-toluenesulfonic acid, yielding a homogeneous liquid. Structural and compositional characterization was performed using FTIR and NMR spectroscopy. The catalytic performance of the synthesized ADES was evaluated in the Pechmann condensation for the synthesis of coumarins. The reaction proceeded under mild conditions using commercially available starting materials, with reaction times ranging from 5 to 200 min and isolated yields between 72% and 97%. The process is operationally simple and readily scalable, indicating its suitability for industrial implementation. Importantly, the ADES demonstrated excellent recyclability, maintaining catalytic activity over five consecutive cycles without significant loss of efficiency which makes it an environmentally friendly and economically viable option for large-scale synthesis.https://doi.org/10.1038/s41598-025-07279-wAcidic deep eutectic solventSustainable catalysisCoumarin synthesisGreen chemistryRecyclable solvent system |
| spellingShingle | Fatemeh Mohammad Najmedin Azizi Zohreh Mirjafari Javad Mokhtari A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis Scientific Reports Acidic deep eutectic solvent Sustainable catalysis Coumarin synthesis Green chemistry Recyclable solvent system |
| title | A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis |
| title_full | A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis |
| title_fullStr | A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis |
| title_full_unstemmed | A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis |
| title_short | A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis |
| title_sort | novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis |
| topic | Acidic deep eutectic solvent Sustainable catalysis Coumarin synthesis Green chemistry Recyclable solvent system |
| url | https://doi.org/10.1038/s41598-025-07279-w |
| work_keys_str_mv | AT fatemehmohammad anovelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT najmedinazizi anovelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT zohrehmirjafari anovelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT javadmokhtari anovelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT fatemehmohammad novelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT najmedinazizi novelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT zohrehmirjafari novelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis AT javadmokhtari novelacidicdeepeutecticsolventforsustainableandefficientcoumarinsynthesis |